RASD1

RAS, dexamethasone-induced 1

Identifiers

RASD1 ; AGS1; DEXRAS1; MGC:26290

External IDs

OMIM: 605550 MGI: 1270848 HomoloGene: 7509 GeneCards: RASD1 Gene

Gene ontology
Molecular function	• GTPase activity • GTP binding
Cellular component	• nucleus • plasma membrane • perinuclear region of cytoplasm
Biological process	• GTP catabolic process • signal transduction • G-protein coupled receptor signaling pathway • nitric oxide mediated signal transduction • small GTPase mediated signal transduction • negative regulation of transcription, DNA-templated
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000108551

ENSMUSG00000049892

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
17.4 – 17.4 Mb

Chr 11:
59.96 – 59.96 Mb

PubMed search

Dexamethasone-induced Ras-related protein 1 is a protein that in humans is encoded by the RASD1 gene.^[1]^[2]

This gene encodes a Ras-related protein that is stimulated by dexamethasone. The exact function of this gene is unknown, but it may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. In addition, studies of a similar rat protein suggest that it functions as a novel physiologic nitric oxide (NO) effector. The gene product belongs to the Ras superfamily of small GTPases.^[2]

Interactions

RASD1 has been shown to interact with NOS1AP.^[3]

References

↑ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (August 2000). "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988.
↑ 2.0 2.1 "Entrez Gene: RASD1 RAS, dexamethasone-induced 1".
↑ Fang, M; Jaffrey S R; Sawa A; Ye K; Luo X; Snyder S H (October 2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron (UNITED STATES) 28 (1): 183–93. doi:10.1016/S0896-6273(00)00095-7. ISSN 0896-6273. PMID 11086993.

Further reading

Kemppainen RJ, Behrend EN (1998). "Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells". J. Biol. Chem. 273 (6): 3129–31. doi:10.1074/jbc.273.6.3129. PMID 9452419.
Cismowski MJ; Takesono A; Ma C et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nat. Biotechnol. 17 (9): 878–83. doi:10.1038/12867. PMID 10471929.
Tu Y, Wu C (2000). "Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone". Biochim. Biophys. Acta 1489 (2–3): 452–6. doi:10.1016/s0167-4781(99)00197-9. PMID 10673050.
Cismowski MJ; Ma C; Ribas C et al. (2000). "Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration". J. Biol. Chem. 275 (31): 23421–4. doi:10.1074/jbc.C000322200. PMID 10840027.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Fang M; Jaffrey SR; Sawa A et al. (2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron 28 (1): 183–93. doi:10.1016/S0896-6273(00)00095-7. PMID 11086993.
Ognjanovic S; Bao S; Yamamoto SY et al. (2001). "Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes". J. Mol. Endocrinol. 26 (2): 107–17. doi:10.1677/jme.0.0260107. PMID 11241162.
Takesono A; Nowak MW; Cismowski M et al. (2002). "Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes". J. Biol. Chem. 277 (16): 13827–30. doi:10.1074/jbc.M201064200. PMID 11842095.
Bi W; Yan J; Stankiewicz P et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jaffrey SR, Fang M, Snyder SH (2003). "Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue". Chem. Biol. 9 (12): 1329–35. doi:10.1016/S1074-5521(02)00293-4. PMID 12498886.
Kemppainen RJ; Cox E; Behrend EN et al. (2003). "Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene". Biochim. Biophys. Acta 1627 (2–3): 85–9. doi:10.1016/s0167-4781(03)00079-4. PMID 12818426.
Vaidyanathan G; Cismowski MJ; Wang G et al. (2004). "The Ras-related protein AGS1/RASD1 suppresses cell growth". Oncogene 23 (34): 5858–63. doi:10.1038/sj.onc.1207774. PMID 15184869.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hiskens R; Vatish M; Hill C et al. (2005). "Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit". Biochem. Biophys. Res. Commun. 337 (4): 1038–46. doi:10.1016/j.bbrc.2005.09.149. PMID 16225846.
Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Nguyen CH, Watts VJ (2006). "Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling". Mol. Pharmacol. 69 (5): 1763–71. doi:10.1124/mol.105.019133. PMID 16489124.
Compton, SL; Behrend, EN; Kemppainen, RJ (December 2009). "Prenylated Rab acceptor domain family member 1 is involved in stimulated ACTH secretion and inhibition". Cellular Signalling 21 (12): 1901–9. doi:10.1016/j.cellsig.2009.08.007. PMID 19733236.