RASA4
| RAS p21 protein activator 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | RASA4 ; CAPRI; GAPL | ||||||||||||
| External IDs | OMIM: 607943 MGI: 1858600 HomoloGene: 5080 GeneCards: RASA4 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10156 | 54153 | |||||||||||
| Ensembl | ENSG00000105808 | ENSMUSG00000004952 | |||||||||||
| UniProt | O43374 | Q6PFQ7 | |||||||||||
| RefSeq (mRNA) | NM_001079877 | NM_001039103 | |||||||||||
| RefSeq (protein) | NP_001073346 | NP_001034192 | |||||||||||
| Location (UCSC) | Chr 7: 102.22 – 102.26 Mb | Chr 5: 136.08 – 136.11 Mb | |||||||||||
| PubMed search | |||||||||||||
Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[1][2]
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
References
- ↑ Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776.
- ↑ 2.0 2.1 "Entrez Gene: RASA4 RAS p21 protein activator 4".
Further reading
- Nagase T, Ishikawa K, Miyajima N et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
- Minagawa T, Fukuda M, Mikoshiba K (2001). "Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538.". Biochem. Biophys. Res. Commun. 288 (1): 87–90. doi:10.1006/bbrc.2001.5740. PMID 11594756.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Liu Q, Walker SA, Gao D et al. (2005). "CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.". J. Cell Biol. 170 (2): 183–90. doi:10.1083/jcb.200504167. PMC 1351313. PMID 16009725.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
External links
- RASA4 human gene location in the UCSC Genome Browser.
- RASA4 human gene details in the UCSC Genome Browser.