RAPGEF6
| Rap guanine nucleotide exchange factor (GEF) 6 | |||||||||||||
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 PDB rendering based on 2d93. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RAPGEF6 ; KIA001LB; PDZ-GEF2; PDZGEF2; RA-GEF-2; RAGEF2 | ||||||||||||
| External IDs | OMIM: 610499 MGI: 2384761 HomoloGene: 22968 GeneCards: RAPGEF6 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51735 | 192786 | |||||||||||
| Ensembl | ENSG00000158987 | ENSMUSG00000037533 | |||||||||||
| UniProt | Q8TEU7 | Q5DTR1 | |||||||||||
| RefSeq (mRNA) | NM_001164386 | NM_001252494 | |||||||||||
| RefSeq (protein) | NP_001157858 | NP_001239423 | |||||||||||
| Location (UCSC) | Chr 5: 130.76 – 130.97 Mb | Chr 11: 54.52 – 54.7 Mb | |||||||||||
| PubMed search | |||||||||||||
Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.[1][2][3]
References
- ↑ Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J Biol Chem 276 (45): 42219–42225. doi:10.1074/jbc.M105760200. PMID 11524421.
- ↑ Kozlov G, Banville D, Gehring K, Ekiel I (Jul 2002). "Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions". J Mol Biol 320 (4): 813–820. doi:10.1016/S0022-2836(02)00544-2. PMID 12095257.
- ↑ "Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6".
Further reading
- Olsen JV; Blagoev B; Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Chen X; Wang X; Hossain S et al. (2006). "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–3342. doi:10.1093/hmg/ddl409. PMID 17030554.
- Beausoleil SA; Jedrychowski M; Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Kuiperij HB; de Rooij J; Rehmann H et al. (2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. Biophys. Acta 1593 (2–3): 141–149. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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