RANBP3
| RAN binding protein 3 | |||||||||||||
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 PDB rendering based on 2crf. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RANBP3 ; DKFZp586I1520 | ||||||||||||
| External IDs | OMIM: 603327 MGI: 1919060 HomoloGene: 136516 GeneCards: RANBP3 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8498 | 71810 | |||||||||||
| Ensembl | ENSG00000031823 | ENSMUSG00000002372 | |||||||||||
| UniProt | Q9H6Z4 | Q9CT10 | |||||||||||
| RefSeq (mRNA) | NM_001300865 | NM_001252466 | |||||||||||
| RefSeq (protein) | NP_001287794 | NP_001239395 | |||||||||||
| Location (UCSC) | Chr 19: 5.92 – 5.98 Mb | Chr 17: 56.67 – 56.71 Mb | |||||||||||
| PubMed search | |||||||||||||
Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.[1][2]
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
Interactions
RANBP3 has been shown to interact with RCC1[1][3] and XPO1.[4][5]
References
- ↑ 1.0 1.1 Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251.
- ↑ 2.0 2.1 "Entrez Gene: RANBP3 RAN binding protein 3".
- ↑ Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. (United States) 277 (20): 17385–8. doi:10.1074/jbc.C100620200. ISSN 0021-9258. PMID 11932251.
- ↑ Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. (United States) 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN 0021-9525. PMC 2150735. PMID 11425870.
- ↑ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell (United States) 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Lindsay ME, Holaska JM, Welch K et al. (2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. PMC 2150735. PMID 11425870.
- Englmeier L, Fornerod M, Bischoff FR et al. (2002). "RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.". EMBO Rep. 2 (10): 926–32. doi:10.1093/embo-reports/kve200. PMC 1084078. PMID 11571268.
- Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.". J. Biol. Chem. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. PMID 11932251.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hakata Y, Yamada M, Shida H (2003). "A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.". Mol. Cell. Biol. 23 (23): 8751–61. doi:10.1128/MCB.23.23.8751-8761.2003. PMC 262658. PMID 14612415.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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