RAI2
| Retinoic acid induced 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbol | RAI2 | ||||||||||||
| External IDs | OMIM: 300217 MGI: 1344378 HomoloGene: 11034 GeneCards: RAI2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10742 | 24004 | |||||||||||
| Ensembl | ENSG00000131831 | ENSMUSG00000043518 | |||||||||||
| UniProt | Q9Y5P3 | Q9QVY8 | |||||||||||
| RefSeq (mRNA) | NM_001172732 | NM_001103367 | |||||||||||
| RefSeq (protein) | NP_001166203 | NP_001096837 | |||||||||||
| Location (UCSC) | Chr X: 17.82 – 17.88 Mb | Chr X: 161.72 – 161.78 Mb | |||||||||||
| PubMed search | |||||||||||||
Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene.[1][2][3]
Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome.[3]
References
- ↑ Walpole SM, Hiriyana KT, Nicolaou A, Bingham EL, Durham J, Vaudin M, Ross MT, Yates JR, Sieving PA, Trump D (May 1999). "Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22". Genomics 55 (3): 275–83. doi:10.1006/geno.1998.5667. PMID 10049581.
- ↑ Walpole SM, Ronce N, Grayson C, Dessay B, Yates JR, Trump D, Toutain A (Jul 1999). "Exclusion of RAI2 as the causative gene for Nance-Horan syndrome". Hum Genet 104 (5): 410–1. doi:10.1007/s004390050976. PMID 10394933.
- ↑ 3.0 3.1 "Entrez Gene: RAI2 retinoic acid induced 2".
Further reading
- Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.