RAG1

Recombination activating gene 1

Identifiers

RAG1 ; RAG-1; RNF74

External IDs

OMIM: 179615 HomoloGene: 387 GeneCards: RAG1 Gene

Gene ontology
Molecular function	• DNA binding • endonuclease activity • ubiquitin-protein transferase activity • protein binding • zinc ion binding • acid-amino acid ligase activity • histone binding • protein homodimerization activity • sequence-specific DNA binding • metal ion binding
Cellular component	• nucleus
Biological process	• adaptive immune response • pre-B cell allelic exclusion • DNA recombination • immune response • histone monoubiquitination • B cell differentiation • T cell differentiation in thymus • V(D)J recombination • T cell homeostasis • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of T cell differentiation • thymus development • protein autoubiquitination • negative regulation of thymocyte apoptotic process • nucleic acid phosphodiester bond hydrolysis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
36.53 – 36.61 Mb

Chr 2:
101.64 – 101.65 Mb

PubMed search

Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.^[1]

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.^[1]

References

↑ 1.0 1.1 "Entrez Gene: Recombination activating gene 1".