RABAC1
| Rab acceptor 1 (prenylated) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | RABAC1 ; PRA1; PRAF1; YIP3 | ||||||||||
| External IDs | OMIM: 604925 MGI: 1201692 HomoloGene: 38182 GeneCards: RABAC1 Gene | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 10567 | 14470 | |||||||||
| Ensembl | ENSG00000105404 | ENSMUSG00000003380 | |||||||||
| UniProt | Q9UI14 | Q9Z0S9 | |||||||||
| RefSeq (mRNA) | NM_006423 | NM_010261 | |||||||||
| RefSeq (protein) | NP_006414 | NP_034391 | |||||||||
| Location (UCSC) | Chr 19: 41.96 – 41.96 Mb | Chr 7: 24.97 – 24.97 Mb | |||||||||
| PubMed search | |||||||||||
RABAC1 is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1.[1][2][3] It is highly conserved in eukaryotes.[1] The protein is localized to Golgi[4] and late endosomes,[5] where it plays a role in vesicular trafficking, lipid transport and cell migration.[6]
Interactions
RABAC1 has been shown to interact with numerous prenylated members of the Rab GTPase family[1][7][8] and VAMP2.[8]
References
- ↑ 1.0 1.1 1.2 Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (Jun 1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem Biophys Res Commun 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
- ↑ Hutt DM, Da-Silva LF, Chang LH, Prosser DC, Ngsee JK (Jul 2000). "PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1". J Biol Chem 275 (24): 18511–9. doi:10.1074/jbc.M909309199. PMID 10751420.
- ↑ "Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)".
- ↑ Abdul-Ghani M; Gougeon PY; Prosser DC et al. (2001). "PRA isoforms are targeted to distinct membrane compartments". J. Biol. Chem. 276 (9): 6225–33. doi:10.1074/jbc.M009073200. PMID 11096102.
- ↑ Sivars U, Aivazian D, Pfeffer SR (2003). "Yip3 catalyses the dissociation of endosomal Rab-GDI complexes". Nature 425 (6960): 856–9. doi:10.1038/nature02057. PMID 14574414.
- ↑ Liu HP, Wu CC, Kao HY et al. (March 2011). "Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration". Mol. Cell Proteomics 10 (3): M900641MCP200. doi:10.1074/mcp.M900641-MCP200. PMC 3047168. PMID 20592422.
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ 8.0 8.1 Martincic, I; Peralta M E; Ngsee J K (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". J. Biol. Chem. (UNITED STATES) 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. ISSN 0021-9258. PMID 9341137.
Further reading
- Martincic I, Peralta ME, Ngsee JK (1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor.". J. Biol. Chem. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.
- Fenster SD; Chung WJ; Zhai R et al. (2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984.
- Figueroa C, Taylor J, Vojtek AB (2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". J. Biol. Chem. 276 (30): 28219–25. doi:10.1074/jbc.M101763200. PMID 11335720.
- Bucci C, De Gregorio L, Bruni CB (2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochem. Biophys. Res. Commun. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
- Evans DT, Tillman KC, Desrosiers RC (2002). "Envelope Glycoprotein Cytoplasmic Domains from Diverse Lentiviruses Interact with the Prenylated Rab Acceptor". J. Virol. 76 (1): 327–37. doi:10.1128/JVI.76.1.327-337.2002. PMC 135700. PMID 11739697.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Blancou P, Evans DT, Desrosiers RC (2005). "PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation". J. Gen. Virol. 86 (Pt 6): 1785–90. doi:10.1099/vir.0.80873-0. PMID 15914857.
- Stelzl U; Worm U; Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Fo CS; Coleman CS; Wallick CJ et al. (2006). "Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2)". Gene 371 (1): 154–65. doi:10.1016/j.gene.2005.12.009. PMID 16481131.
- Liu HP, Wu CC, Chang YS (2006). "PRA1 promotes the intracellular trafficking and NF-κB signaling of EBV latent membrane protein 1". EMBO J. 25 (17): 4120–30. doi:10.1038/sj.emboj.7601282. PMC 1560356. PMID 16917502.
- Kim JT; Cho MY; Choi SC et al. (2006). "Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin". Biochem. Biophys. Res. Commun. 349 (1): 200–8. doi:10.1016/j.bbrc.2006.08.026. PMID 16930546.
- Dickison VM, Richmond AM, Abu Irqeba A, Martak JG, Hoge SCE, Brooks MJ, Othman MI, Khanna R, Mears AJ, Chowdhury AY, Swaroop A, Ogilvie JM (2012). "A role for prenylated rab acceptor 1 in vertebrate photoreceptor development". BMC Neurosci 13: 152. doi:10.1186/1471-2202-13-152. PMC 3576285. PMID 23241222.