RAB8A
Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.[1][2][3]
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.[3]
Interactions
RAB8A has been shown to interact with Optineurin[4] and MAP4K2.[5]
References
- ↑ Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (October 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene 6 (8): 1347–51. PMID 1886711.
- ↑ Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K (November 1993). "Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane". J Cell Biol 123 (1): 35–45. doi:10.1083/jcb.123.1.35. PMC 2119815. PMID 8408203.
- ↑ 3.0 3.1 "Entrez Gene: RAB8A RAB8A, member RAS oncogene family".
- ↑ Hattula, K; Peränen J (2000). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Curr. Biol. (England) 10 (24): 1603–6. doi:10.1016/S0960-9822(00)00864-2. ISSN 0960-9822. PMID 11137014.
- ↑ Ren, M; Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini D D (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. ISSN 0027-8424. PMC 39423. PMID 8643544.
Further reading
- Newport J, Roemer MI (1975). "Comparative perinatal mortality under medical care foundations and other delivery models". Inquiry : a journal of medical care organization, provision and financing 12 (1): 10–7. PMID 123217.
- Nimmo E, Padua RA, Hughes D et al. (1989). "Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping". Hum. Genet. 81 (4): 382–4. doi:10.1007/BF00283697. PMID 2564840.
- Zahraoui A, Joberty G, Arpin M et al. (1994). "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells". J. Cell Biol. 124 (1–2): 101–15. doi:10.1083/jcb.124.1.101. PMC 2119893. PMID 8294494.
- Joberty G, Tavitian A, Zahraoui A (1993). "Isoprenylation of Rab proteins possessing a C-terminal CaaX motif". FEBS Lett. 330 (3): 323–8. doi:10.1016/0014-5793(93)80897-4. PMID 8375503.
- Ren M, Zeng J, De Lemos-Chiarandini C et al. (1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. PMC 39423. PMID 8643544.
- Bähler M, Kehrer I, Gordon L et al. (1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
- Wilson AL, Erdman RA, Castellano F, Maltese WA (1998). "Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases". Biochem. J. 333 (Pt 3): 497–504. PMC 1219609. PMID 9677305.
- Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381.
- Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry 38 (36): 11711–21. doi:10.1021/bi990200r. PMID 10512627.
- Hattula K, Peränen J (2001). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Curr. Biol. 10 (24): 1603–6. doi:10.1016/S0960-9822(00)00864-2. PMID 11137014.
- Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
- Hattula K, Furuhjelm J, Arffman A, Peränen J (2003). "A Rab8-specific GDP/GTP Exchange Factor Is Involved in Actin Remodeling and Polarized Membrane Transport". Mol. Biol. Cell 13 (9): 3268–80. doi:10.1091/mbc.E02-03-0143. PMC 124888. PMID 12221131.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
- Lau AS, Mruk DD (2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Linder MD, Uronen RL, Hölttä-Vuori M et al. (2007). "Rab8-dependent Recycling Promotes Endosomal Cholesterol Removal in Normal and Sphingolipidosis Cells". Mol. Biol. Cell 18 (1): 47–56. doi:10.1091/mbc.E06-07-0575. PMC 1751315. PMID 17050734.
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