RAB5B

RAB5B, member RAS oncogene family

PDB rendering based on 1huq.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2HEI

Identifiers

Symbol

RAB5B

External IDs

OMIM: 179514 HomoloGene: 104027 GeneCards: RAB5B Gene

Gene ontology
Molecular function	• GTPase activity • protein binding • GTP binding • GDP binding • GTP-dependent protein binding
Cellular component	• intracellular • endosome • plasma membrane • membrane • endocytic vesicle • early endosome membrane • melanosome • extracellular vesicular exosome
Biological process	• GTP catabolic process • endosome organization • small GTPase mediated signal transduction • protein transport • antigen processing and presentation • regulation of endocytosis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
56.37 – 56.39 Mb

Chr 10:
128.68 – 128.7 Mb

PubMed search

Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.^[1]^[2]^[3]

References

↑ Wilson DB, Wilson MP (Apr 1992). "Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases". J Clin Invest 89 (3): 996–1005. doi:10.1172/JCI115683. PMC 442949. PMID 1541686.
↑ Chiariello M, Bruni CB, Bucci C (Aug 1999). "The small GTPases Rab5a, Rab5b and Rab5c are differentially phosphorylated in vitro". FEBS Lett 453 (1-2): 20–4. doi:10.1016/S0014-5793(99)00686-9. PMID 10403367.
↑ "Entrez Gene: RAB5B RAB5B, member RAS oncogene family".

Bucci C, Lütcke A, Steele-Mortimer O, Olkkonen VM, Dupree P, Chiariello M, Bruni CB, Simons K, Zerial M (1995). "Co-operative regulation of endocytosis by three Rab5 isoforms.". FEBS Lett. 366 (1): 65–71. doi:10.1016/0014-5793(95)00477-Q. PMID 7789520.
Korenberg JR, Chen XN, Adams MD, Venter JC (1996). "Toward a cDNA map of the human genome.". Genomics 29 (2): 364–70. doi:10.1006/geno.1995.9993. PMID 8666383.
Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381.
Callaghan J, Nixon S, Bucci C, Toh BH, Stenmark H (1999). "Direct interaction of EEA1 with Rab5b.". Eur. J. Biochem. 265 (1): 361–6. doi:10.1046/j.1432-1327.1999.00743.x. PMID 10491193.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.". Dev. Cell 1 (1): 73–82. doi:10.1016/S1534-5807(01)00008-9. PMID 11703925.
Saito K, Murai J, Kajiho H, Kontani K, Kurosu H, Katada T (2002). "A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.". J. Biol. Chem. 277 (5): 3412–8. doi:10.1074/jbc.M106276200. PMID 11733506.
Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, Katada T (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.". J. Cell. Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Hirota Y, Kuronita T, Fujita H, Tanaka Y (2007). "A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartments.". Biochem. Biophys. Res. Commun. 364 (1): 40–7. doi:10.1016/j.bbrc.2007.09.089. PMID 17927960.

PDB gallery

1huq: 1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE)

1z07: GppNHp-Bound Rab5c G55Q mutant GTPase

1z0d: GDP-Bound Rab5c GTPase

2hei: Crystal structure of human RAB5B in complex with GDP

RAB5B

References

Further reading