RAB3B

RAB3B, member RAS oncogene family

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3DZ8

Identifiers

Symbol

RAB3B

External IDs

OMIM: 179510 MGI: 1917158 HomoloGene: 2149 GeneCards: RAB3B Gene

Gene ontology
Molecular function	• GTP binding • GDP binding
Cellular component	• cytoplasm • cytosol • plasma membrane • synaptic vesicle • secretory granule • vesicle • perinuclear region of cytoplasm • extracellular vesicular exosome
Biological process	• small GTPase mediated signal transduction • protein transport • regulation of exocytosis • peptidyl-cysteine methylation • antigen processing and presentation • positive regulation of dopamine uptake involved in synaptic transmission • regulation of vesicle size
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
52.37 – 52.46 Mb

Chr 4:
108.88 – 108.94 Mb

PubMed search

Ras-related protein Rab-3B is a protein that in humans is encoded by the RAB3B gene.^[1]

Interactions

RAB3B has been shown to interact with RPH3A.^[2]^[3]

References

↑ "Entrez Gene: RAB3B RAB3B, member RAS oncogene family".
↑ Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. (United States) 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829.
↑ Weber, E; Jilling T; Kirk K L (Mar 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J. Biol. Chem. (UNITED STATES) 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. ISSN 0021-9258. PMID 8636125.

Rousseau-Merck MF, Zahraoui A, Touchot N et al. (1991). "Chromosome assignment of four RAS-related RAB genes.". Hum. Genet. 86 (4): 350–4. doi:10.1007/BF00201831. PMID 1999336.
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.". J. Biol. Chem. 264 (21): 12394–401. PMID 2501306.
Weber E, Berta G, Tousson A et al. (1994). "Expression and polarized targeting of a rab3 isoform in epithelial cells.". J. Cell Biol. 125 (3): 583–94. doi:10.1083/jcb.125.3.583. PMC 2119989. PMID 8175882.
Weber E, Jilling T, Kirk KL (1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells.". J. Biol. Chem. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. PMID 8636125.
Regazzi R, Ravazzola M, Iezzi M et al. (1997). "Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells.". J. Cell. Sci. 109 (9): 2265–73. PMID 8886977.
Sidhu RS, Bhullar RP (2002). "Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin.". Biochem. Biophys. Res. Commun. 289 (5): 1039–43. doi:10.1006/bbrc.2001.6113. PMID 11741295.
van IJzendoorn SC, Tuvim MJ, Weimbs T et al. (2002). "Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells.". Dev. Cell 2 (2): 219–28. doi:10.1016/S1534-5807(02)00115-6. PMID 11832247.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Yamamoto Y, Nishimura N, Morimoto S et al. (2003). "Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane.". Biochem. Biophys. Res. Commun. 308 (2): 270–5. doi:10.1016/S0006-291X(03)01358-5. PMID 12901864.
Matsumoto M, Miki T, Shibasaki T et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

RAB3B

Interactions

References

Further reading