RAB1A

RAB1A, member RAS oncogene family

PDB rendering based on 2fol.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsRAB1A ; RAB1; YPT1
External IDsOMIM: 179508 MGI: 97842 HomoloGene: 36154 GeneCards: RAB1A Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez586119324
EnsemblENSG00000138069ENSMUSG00000020149
UniProtP62820P62821
RefSeq (mRNA)NM_004161NM_008996
RefSeq (protein)NP_004152NP_033022
Location (UCSC)Chr 2:
65.3 – 65.36 Mb
Chr 11:
20.2 – 20.23 Mb
PubMed search

Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene.[1][2]

Interactions

RAB1A has been shown to interact with CHM,[3] GOLGA5,[4][5] CHML,[3][6] RABAC1,[7][8] MICAL1[9] and GOLGA2.[9][10][11]

References

  1. Zahraoui A, Touchot N, Chardin P, Tavitian A (August 1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". J Biol Chem 264 (21): 12394–401. PMID 2501306.
  2. "Entrez Gene: RAB1A RAB1A, member RAS oncogene family".
  3. 3.0 3.1 Cremers, F P; Armstrong S A; Seabra M C; Brown M S; Goldstein J L (January 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". J. Biol. Chem. (UNITED STATES) 269 (3): 2111–7. ISSN 0021-9258. PMID 8294464.
  4. Satoh, Ayano; Wang Yanzhuang; Malsam Jörg; Beard Matthew B; Warren Graham (March 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic (Denmark) 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. ISSN 1398-9219. PMID 12656988.
  5. Diao, Aipo; Rahman Dinah; Pappin Darryl J C; Lucocq John; Lowe Martin (January 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". J. Cell Biol. (United States) 160 (2): 201–12. doi:10.1083/jcb.200207045. ISSN 0021-9525. PMC 2172652. PMID 12538640.
  6. Anant, J S; Desnoyers L; Machius M; Demeler B; Hansen J C; Westover K D; Deisenhofer J; Seabra M C (September 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry (UNITED STATES) 37 (36): 12559–68. doi:10.1021/bi980881a. ISSN 0006-2960. PMID 9730828.
  7. Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. Martincic, I; Peralta M E; Ngsee J K (October 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". J. Biol. Chem. (UNITED STATES) 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. ISSN 0021-9258. PMID 9341137.
  9. 9.0 9.1 Weide, Thomas; Teuber Julia; Bayer Michael; Barnekow Angelika (June 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. (United States) 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN 0006-291X. PMID 12788069.
  10. Valsdottir, R; Hashimoto H; Ashman K; Koda T; Storrie B; Nilsson T (November 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Lett. (Netherlands) 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. ISSN 0014-5793. PMID 11718716.
  11. Short, B; Preisinger C; Körner R; Kopajtich R; Byron O; Barr F A (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. (United States) 155 (6): 877–83. doi:10.1083/jcb.200108079. ISSN 0021-9525. PMC 2150909. PMID 11739401.

Further reading