RAB11A

RAB11A, member RAS oncogene family

PDB rendering based on 1oiv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsRAB11A ; YL8
External IDsOMIM: 605570 MGI: 1858202 HomoloGene: 37903 GeneCards: RAB11A Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez876653869
EnsemblENSG00000103769ENSMUSG00000004771
UniProtP62491P62492
RefSeq (mRNA)NM_001206836NM_017382
RefSeq (protein)NP_001193765NP_059078
Location (UCSC)Chr 15:
66.02 – 66.18 Mb		Chr 9:
64.72 – 64.74 Mb
PubMed search

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.[1][2]

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport.[3]

Interactions

RAB11A has been shown to interact with RAB11FIP2,[4][5][6] RAB11FIP4,[7] RAB11FIP1,[5][8][9] RAB11FIP5[5][6][10] and RAB11FIP3.[5] Researchers from NTNU has shown Rab-11a to control intracellular trafficking of the innate immune receptor TLR4, and thereby also receptor signalling[11] .

References

  1. ↑ Drivas GT, Shih A, Coutavas EE, D'Eustachio P, Rush MG (March 1991). "Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3". Oncogene 6 (1): 3–9. PMID 1704119.
  2. ↑ Gromov PS, Celis JE, Hansen C, Tommerup N, Gromova I, Madsen P (July 1998). "Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins". FEBS Lett 429 (3): 359–64. doi:10.1016/S0014-5793(98)00607-3. PMID 9662449.
  3. ↑ "Entrez Gene: RAB11A RAB11A, member RAS oncogene family".
  4. ↑ Lindsay, Andrew J; McCaffrey Mary W (July 2002). "Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain". J. Biol. Chem. (United States) 277 (30): 27193–9. doi:10.1074/jbc.M200757200. ISSN 0021-9258. PMID 11994279.
  5. ↑ 5.0 5.1 5.2 5.3 Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. (United States) 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.
  6. ↑ 6.0 6.1 Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. (United States) 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.
  7. ↑ Wallace, Deborah M E; Lindsay Andrew J; Hendrick Alan G; McCaffrey Mary W (Dec 2002). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. (United States) 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. ISSN 0006-291X. PMID 12470645.
  8. ↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ↑ Lindsay, Andrew J; Hendrick Alan G, Cantalupo Giuseppina, Senic-Matuglia Francesca, Goud Bruno, Bucci Cecilia, McCaffrey Mary W (April 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J. Biol. Chem. (United States) 277 (14): 12190–9. doi:10.1074/jbc.M108665200. ISSN 0021-9258. PMID 11786538.
  10. ↑ Prekeris, R; Klumperman J; Scheller R H (Dec 2000). "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes". Mol. Cell (United States) 6 (6): 1437–48. doi:10.1016/S1097-2765(00)00140-4. ISSN 1097-2765. PMID 11163216.
  11. ↑ Espevik T, Husebye H, Aune MH, Stenvik J; Samstad E; Skjeldal F; Halaas O; Nilsen NJ; Stenmark H; Latz E; Lien E; Mollnes TE; Bakke O (October 2010). "The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes". Immunity 33 (4): 583–596. doi:10.1016/j.immuni.2010.09.010. PMID 20933442.

Further reading

  • Sakurada K, Uchida K, Yamaguchi K et al. (1991). "Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver". Biochem. Biophys. Res. Commun. 177 (3): 1224–32. doi:10.1016/0006-291X(91)90672-T. PMID 1711847.
  • Gromov P, Celis JE (1998). "Rab11a is modified in vivo by isoprenoid geranylgeranyl". Electrophoresis 19 (10): 1803–7. doi:10.1002/elps.1150191043. PMID 9719562.
  • Zeng J, Ren M, Gravotta D et al. (1999). "Identification of a putative effector protein for rab11 that participates in transferrin recycling". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2840–5. doi:10.1073/pnas.96.6.2840. PMC 15856. PMID 10077598.
  • Dumanchin C, Czech C, Campion D et al. (1999). "Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport". Hum. Mol. Genet. 8 (7): 1263–9. doi:10.1093/hmg/8.7.1263. PMID 10369872.
  • Mammoto A, Ohtsuka T, Hotta I et al. (1999). "Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling". J. Biol. Chem. 274 (36): 25517–24. doi:10.1074/jbc.274.36.25517. PMID 10464283.
  • Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry 38 (36): 11711–21. doi:10.1021/bi990200r. PMID 10512627.
  • Prekeris R, Klumperman J, Scheller RH (2001). "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes". Mol. Cell 6 (6): 1437–48. doi:10.1016/S1097-2765(00)00140-4. PMID 11163216.
  • Lapierre LA, Kumar R, Hales CM et al. (2001). "Myosin Vb Is Associated with Plasma Membrane Recycling Systems". Mol. Biol. Cell 12 (6): 1843–57. doi:10.1091/mbc.12.6.1843. PMC 37346. PMID 11408590.
  • Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
  • Hales CM, Griner R, Hobdy-Henderson KC et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
  • Lindsay AJ, Hendrick AG, Cantalupo G et al. (2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J. Biol. Chem. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
  • Lindsay AJ, McCaffrey MW (2002). "Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain". J. Biol. Chem. 277 (30): 27193–9. doi:10.1074/jbc.M200757200. PMID 11994279.
  • Scales SJ, Hesser BA, Masuda ES, Scheller RH (2002). "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly". J. Biol. Chem. 277 (31): 28271–9. doi:10.1074/jbc.M204929200. PMID 12145319.
  • Band AM, Ali H, Vartiainen MK et al. (2002). "Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton". FEBS Lett. 531 (3): 513–9. doi:10.1016/S0014-5793(02)03605-0. PMID 12435603.
  • Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Roosterman D, Schmidlin F, Bunnett NW (2003). "Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2". Am. J. Physiol., Cell Physiol. 284 (5): C1319–29. doi:10.1152/ajpcell.00540.2002. PMID 12540381.
  • Tani K, Shibata M, Kawase K et al. (2003). "Mapping of functional domains of gamma-SNAP". J. Biol. Chem. 278 (15): 13531–8. doi:10.1074/jbc.M213205200. PMID 12554740.