Pseudouridine
 | |
| Names | |
|---|---|
| IUPAC name
5-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-oxolan-2-yl]-1H-pyrimidine-2,4-dione | |
| Preferred IUPAC name
5-(β-D-ribofuranosyl)pyrimidine-2,4(1H,3H)-dione | |
| Other names
psi-Uridine, 5-Ribosyluracil, beta-D-Pseudouridine, 5-(beta-D-Ribofuranosyl)uracil | |
| Identifiers | |
1445-07-4  | |
| ChEBI | CHEBI:17802  |
| ChemSpider | 14319 |
| |
| Jmol-3D images | Image |
| PubChem | 15047 |
| |
| Properties | |
| C9H12N2O6 | |
| Molar mass | 244.20 g/mol |
| Appearance | White granular powder |
| Highly soluble in water. | |
| Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| verify (what is: /?) | |
| Infobox references | |
Pseudouridine (abbreviated by the Greek letter psi- Ψ) is the C-glycoside isomer of the nucleoside uridine, and it is the most prevalent of the over one hundred different modified nucleosides found in RNA.[1] Ψ is found in all species and in many classes of RNA.[2][3] [4][5] Ψ is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation.[6]
Pseudouridine is biosynthesized from uridine via the action of Ψ synthases.
It is commonly found in tRNA, associated with thymidine and cytosine in the TΨC arm and is one of the invariant regions of tRNA.The function of it is not very clear, but it is expected to play a role in association with aminoacyl transferases during their interaction with tRNA, and hence in the initiation of translation. Recent studies suggest it may offer protection from radiation.[7]
A tRNAAla from S. cerevisiae.
Pseudouridine = Ψ
See also
- Pseudouridine kinase
- TRNA-pseudouridine synthase
References
- ↑ Hamma T, Ferré-D'Amaré AR (2006). "Pseudouridine synthases". Chem. Biol. 13 (11): 1125–1135. doi:10.1016/j.chembiol.2006.09.009. PMID 17113994.
- ↑ Charette M, Gray MW (2000). "Pseudouridine in RNA: what, where, how, and why". IUBMB Life 49 (5): 341–351. doi:10.1080/152165400410182. PMID 10902565.
- ↑ Liang XH, Xu YX, MIchaeli S (2002). "The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA". RNA 8 (2): 237–246. doi:10.1017/S1355838202018290. PMC 1370245. PMID 11911368.
- ↑ Carlile, Thomas (2014-09-05). "Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells". Nature. doi:10.1038/nature13802.
- ↑ Schwartz, Schraga (2014-09-11). "Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA". Cell. doi:10.1016/j.cell.2014.08.028.
- ↑ Ferré-D'Amaré AR (2003). "RNA-modifying enzymes". Curr. Opin. Struct. Biol. 13 (1): 49–55. doi:10.1016/S0959-440X(02)00002-7. PMID 12581659.
- ↑ Monobe, Manami; Arimoto-Kobayashi, Sakae; Ando, Koichi (2003). "β-Pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes". Mutation research. Genetic toxicology and environmental mutagenesis 538 (1–2): 93–99. doi:10.1016/S1383-5718(03)00094-9. PMID 12834758.