Protein SET

SET nuclear proto-oncogene

PDB rendering based on 2e50.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2E50

Identifiers

Symbols

SET ; 2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; TAF-I; TAF-IBETA

External IDs

OMIM: 600960 MGI: 1860267 HomoloGene: 55707 GeneCards: SET Gene

Gene ontology
Molecular function	• DNA binding • protein phosphatase inhibitor activity • protein binding • protein phosphatase type 2A regulator activity • histone binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • endoplasmic reticulum • cytosol • protein complex • perinuclear region of cytoplasm
Biological process	• mitotic cell cycle • DNA replication • nucleosome assembly • nucleosome disassembly • nucleocytoplasmic transport • gene expression • RNA metabolic process • mRNA metabolic process • negative regulation of histone acetylation • negative regulation of catalytic activity • negative regulation of neuron apoptotic process • negative regulation of transcription, DNA-templated • regulation of catalytic activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
131.45 – 131.46 Mb

Chr 2:
30.06 – 30.07 Mb

PubMed search

Protein SET is a protein that in humans is encoded by the SET gene.^[1]^[2]^[3]

Interactions

Protein SET has been shown to interact with TAF1A,^[4] NME1,^[5] CDK5R1,^[6] Acidic leucine-rich nuclear phosphoprotein 32 family member A^[4]^[7] and KLF5.^[8]

References

↑ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Mol Cell Biol 12 (8): 3346–55. PMC 364582. PMID 1630450.
↑ Li M, Makkinje A, Damuni Z (Jun 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". J Biol Chem 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647.
↑ "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".
↑ 4.0 4.1 Seo, S B; McNamara P; Heo S; Turner A; Lane W S; Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell (United States) 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. ISSN 0092-8674. PMID 11163245.
↑ Fan, Zusen; Beresford Paul J; Oh David Y; Zhang Dong; Lieberman Judy (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell (United States) 112 (5): 659–72. doi:10.1016/S0092-8674(03)00150-8. ISSN 0092-8674. PMID 12628186.
↑ Qu, Dianbo; Li Qing; Lim Hui-Ying; Cheung Nam Sang; Li Rong; Wang Jerry H; Qi Robert Z (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". J. Biol. Chem. (United States) 277 (9): 7324–32. doi:10.1074/jbc.M107270200. ISSN 0021-9258. PMID 11741927.
↑ Fan, Zusen; Beresford Paul J; Zhang Dong; Lieberman Judy (Apr 2002). "HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A". Mol. Cell. Biol. (United States) 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. ISSN 0270-7306. PMC 133744. PMID 11909973.
↑ Miyamoto, Saku; Suzuki Toru, Muto Shinsuke, Aizawa Kenichi, Kimura Akatsuki, Mizuno Yoshiko, Nagino Tomoko, Imai Yasushi, Adachi Naruhiko, Horikoshi Masami, Nagai Ryozo (Dec 2003). "Positive and Negative Regulation of the Cardiovascular Transcription Factor KLF5 by p300 and the Oncogenic Regulator SET through Interaction and Acetylation on the DNA-Binding Domain". Mol. Cell. Biol. (United States) 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. ISSN 0270-7306. PMC 262669. PMID 14612398.

Nagata K, Kawase H, Handa H et al. (1995). "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis". Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4279–83. doi:10.1073/pnas.92.10.4279. PMC 41927. PMID 7753797.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Adachi Y, Pavlakis GN, Copeland TD (1994). "Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia". FEBS Lett. 340 (3): 231–5. doi:10.1016/0014-5793(94)80144-4. PMID 8131851.
Vaesen M, Barnikol-Watanabe S, Götz H et al. (1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biol. Chem. Hoppe-Seyler 375 (2): 113–26. doi:10.1515/bchm3.1994.375.2.113. PMID 8192856.
Adachi Y, Pavlakis GN, Copeland TD (1994). "Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia". J. Biol. Chem. 269 (3): 2258–62. PMID 8294483.
Adler HT, Nallaseth FS, Walter G, Tkachuk DC (1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". J. Biol. Chem. 272 (45): 28407–14. doi:10.1074/jbc.272.45.28407. PMID 9353299.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Carlson SG, Eng E, Kim EG et al. (1999). "Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor". J. Am. Soc. Nephrol. 9 (10): 1873–80. PMID 9773788.
Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
Shikama N, Chan HM, Krstic-Demonacos M et al. (2000). "Functional Interaction between Nucleosome Assembly Proteins and p300/CREB-Binding Protein Family Coactivators". Mol. Cell. Biol. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC 86548. PMID 11073993.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Seo SB, McNamara P, Heo S et al. (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
Minakuchi M, Kakazu N, Gorrin-Rivas MJ et al. (2001). "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET". Eur. J. Biochem. 268 (5): 1340–51. doi:10.1046/j.1432-1327.2001.02000.x. PMID 11231286.
Beresford PJ, Zhang D, Oh DY et al. (2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". J. Biol. Chem. 276 (46): 43285–93. doi:10.1074/jbc.M108137200. PMID 11555662.
Gallouzi IE, Brennan CM, Steitz JA (2001). "Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock". RNA 7 (9): 1348–61. doi:10.1017/S1355838201016089. PMC 1370177. PMID 11565755. (Retracted. If this is intentional, please replace {{Retracted}} with {{Retracted|intentional=yes}}.)
Qu D, Li Q, Lim HY et al. (2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". J. Biol. Chem. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
Fan Z, Beresford PJ, Zhang D, Lieberman J (2002). "HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A". Mol. Cell. Biol. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
Cervoni N, Detich N, Seo SB et al. (2002). "The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing". J. Biol. Chem. 277 (28): 25026–31. doi:10.1074/jbc.M202256200. PMID 11978794.

PDB gallery

2e50: Crystal structure of SET/TAF-1beta/INHAT

Protein SET

Interactions

References

Further reading