Proteasome endopeptidase complex

Proteasome endopeptidase complex
Identifiers
EC number 3.4.25.1
CAS number 140879-24-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Proteasome endopeptidase complex (EC 3.4.25.1, ingensin, macropain, multicatalytic endopeptidase complex, prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn proteinase, tricorn protease) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Cleavage of peptide bonds with very broad specificity

This 20-S protein is composed of 28 subunits arranged in four rings of seven.

References

  1. ↑ Seemüller, E., Lupas, A., Stock, D., Löwe, J., Huber, R. and Baumeister, W. (1995). "Proteasome from Thermoplasma acidophilum: a threonine protease". Science 268 (5210): 579–582. doi:10.1126/science.7725107. PMID 7725107.
  2. ↑ Coux, O., Tanaka, K. and Goldberg, A.L. (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–847. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
  3. ↑ Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H.D. and Huber, R. (1997). "Structure of 20S proteasome from yeast at 2.4Å resolution". Nature 386 (6624): 463–471. doi:10.1038/386463a0. PMID 9087403.
  4. ↑ Dick, T.P., Nussbaum, A.K., Deeg, M., Heinemeyer, W., Groll, M., Schirle, M., Keilholz, W., Stevanovic, S., Wolf, D.H., Huber, R., Rammensee, H.G. and Schild, H. (1998). "Contribution of proteasomal β-subunits to the cleavage of peptide substrates analyzed with yeast mutants". J. Biol. Chem. 273 (40): 25637–25646. doi:10.1074/jbc.273.40.25637. PMID 9748229.

External links