Prosultiamine
Prosultiamine (Alinamin, Binova, Jubedel, Taketron, Thiobeta, Thiotiamina), also known as thiamine propyl disulfide (TPD), is a disulfide thiamine derivative developed in Japan in the 1950s as a treatment for vitamin B1 deficiency.[1][2] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.[3][4] It is also a potential treatment for HTLV, since it has been shown to reduce viral load and symptoms.[5]
See also
References
- ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
- ↑ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
- ↑ Thomson AD, Frank O, Baker H, Leevy CM (April 1971). "Thiamine propyl disulfide: absorption and utilization". Annals of Internal Medicine 74 (4): 529–34. doi:10.7326/0003-4819-74-4-529. PMID 5551161.
- ↑ Baker H, Frank O (August 1976). "Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines". Journal of Nutritional Science and Vitaminology. 22 SUPPL: 63–8. PMID 978282.
- ↑ Nervous System Disease: A New Outlet for an Old Drug?
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- Vitamins
- Cofactors
- Metal metabolism
- Fats
- metabolism
- intermediates
- lipoproteins
- Sugars
- Glycolysis
- Glycogenesis and glycogenolysis
- Fructose and galactose
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- Vitamins
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- Drugs
- Vitamins
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