Propizepine

Propizepine
Systematic (IUPAC) name
6-(2-dimethylaminopropyl)-11H-pyrido[3,2-c][1,5]benzodiazepin-5-one
Clinical data
  • ℞ (Prescription only)
Oral
Identifiers
10321-12-7
14559-79-6 (hydrochloride)
None
PubChem CID 112029
ChemSpider 100443
UNII 09B57945V9 Yes
ChEMBL CHEMBL2104749
Chemical data
Formula C17H20N4O
296.37 g/mol

Propizepine (Depressin, Vagran) is a tricyclic antidepressant (TCA) used in France for the treatment of depression which was introduced in the 1970s.[1][2][3][4]

Synthesis

Propizepine can be synthesized by the condensation of 2-chloronicotinic acid with o-phenylenediamine followed by alkylation of the resulting lactam with 3-chloro-2-(N,N-dimethylamino)propane.[5]

Propizepine synthesis

References

  1. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 888. ISBN 3-88763-075-0.
  2. ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. p. 1680. ISBN 0-412-46630-9.
  3. ↑ Niels F. Muller, Rudolf P. Dessing, European Society of Clinical Pharmacy (1997). European Drug Index, Volume 33. CRC Press. p. 1339. ISBN 3-7692-2114-1.
  4. ↑ Dereux JF (1976). "[Vagran 50: a situational antidepressant]". Semaine des Hôpitaux. Thérapeutique (in French) 52 (7-8): 385–8. PMID 996559.
  5. ↑ Hoffmann, C.; Faure, A.; Bull. Soc. Chim. Fr. 1966, 2316.