Promescent

Promescent is a topical medication[1] for the treatment of premature ejaculation. It is made by Absorption Pharmaceuticals and is available over-the-counter in the U.S. by way of FDA Monograph 21CFR 348.10.[2]

History

Promescent was invented in 2009 by doctor Ronald F. Gilbert, former chief of the Department of Urology at Hoag Hospital and assistant clinical professor of urology at UCI Medical School.[3]

Urologists had been encouraged by the success of two topical anesthetics with fast absorption lidocaine/prilocaine eutectic formulations: EMLA[4] and PSD502.[5] However, neither of the products are approved by the FDA[6] specifically for the treatment of PE due to prilocaine's unusual side effect of methemoglobinemia.

Technology

Gilbert sought a eutectic formulation with maximum absorption rate through the penile skin without the use of prilocaine. The U.S. Patent and Trademark Office has granted to Absorption Pharmaceuticals the following patents related to the technology of Promescent:

Patent No. Date of Issue Overview Description
8,507,561 13Aug2013 Formula application to premature ejaculation
8,563,616 22Oct2013 Composition of lidocaine-only eutectic formula
8,637,577 28Jan2014 Additional eutectic formulations

These patents protect novel lidocaine-only eutectic formulations which enable increased absorption of the anesthetic through the skin. [7] [8] [9]

Cultural

Promescent has sparked numerous articles in the media about the increase awareness of premature ejaculation as the leading male sexual dysfunction[10] and the effectiveness and practicality of various topical treatments.[11][12][13] In October, 2013, Promescent was highlighted in a story on CNBC television and website entitled "Move over, Viagra. There's a new sex drug in town."[14]

On February 25, 2014, Mr. Skin was on the Howard Stern SiriusXM radio show describing the benefits of Promescent. Mr. Skin said "...let's say you're 5 second guy, you'll become 5 minute guy; and if you're a 5 minute guy, you'll become a 25 minute guy." Upon which Howard exclaimed enthusiastically, "Wow! These guys are geniuses!"

References

  1. ↑ US National Library of Medicine/National Institute of Health/DailyMed http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5b508238-3be7-4b0d-bf35-51de79f58f55
  2. ↑ U.S. Food and Drug Administration (FDA) External Analgesic Drug Products for Over-The-Counter Human Use http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?CFRPart=348&showFR=1
  3. ↑ "Ronald F. Gilbert, M.D., F.A.C.S., Newport Beach Urologist, Urology Specialist Orange County". Orangecoasturology.com. Archived from the original on 2013-05-27. Retrieved 2013-11-01.
  4. ↑ Atan, A. Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation, Urology, 2006 Feb; 67(2):388-91
  5. ↑ Carson, C. Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study; J Sex Med 2010 Sep 7(9):3179-89. doi: 10.1111/j.1743-6109.2010.01913.x
  6. ↑ "Urology Care Foundation - Urology A-Z - Premature Ejaculation (PE)". Urologyhealth.org. Retrieved 2013-11-01.
  7. ↑ Desensitizing drug product US 8507561 B2, http://www.google.com/patents/US8507561
  8. ↑ Desensitizing drug product US 8563616 B2, https://www.google.com/patents/US8563616
  9. ↑ Desensitizing drug product US 8637577 B2, https://www.google.com/patents/US8637577
  10. ↑ Cleveland Clinic Sexual Dysfunction in Males http://my.clevelandclinic.org/disorders/sexual_dysfunction/hic_sexual_dysfunction_in_males.aspx
  11. ↑ Ian Kerner, PE: The 'other' male sexual problem, CNN Health 3 May 2012
  12. ↑ What's With These New Lidocaine Sprays? Should I Try One? Esquire Magazine, February 2013
  13. ↑ The Atlantic http://www.theatlantic.com/health/archive/2012/11/when-is-ejaculation-premature-and-when-should-a-penis-be-made-numb/265071/ 12 November 2012
  14. ↑ Jane Wells (2013-10-03). "Move over, Viagra. There's a new sex drug in town". Cnbc.com. Retrieved 2013-11-01.

External links