Prokaryotic elongation factors

EF-Tu was PDB Molecule of the Month pdb81_1 on September 2006

In prokaryotes, four elongation factors are required for translation: EF-Tu, EF-Ts, EF-G and EF-P.

• EF-Tu mediates the entry of the aminoacyl tRNA into a free site of the ribosome.
• EF-Ts serves as the guanine nucleotide exchange factor for EF-Tu, catalyzing the release of GDP from EF-Tu.
• EF-G catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation.
• EF-P stimulates peptide formation by catalyzing the first synthesis step between the first amino acid (N-formylmethionine) and the second amino acid.

See also

• Elongation factor
• Eukaryotic elongation factor

External links

• Peptide Elongation Factor G at the US National Library of Medicine Medical Subject Headings (MeSH)
• Peptide Elongation Factor Tu at the US National Library of Medicine Medical Subject Headings (MeSH)