Proglumetacin

Proglumetacin
Systematic (IUPAC) name

3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N²-benzoyl-N,N-dipropyl-α-glutaminate
Clinical data
AHFS/Drugs.com	International Drug Names
Pharmacokinetic data
Metabolism	Hepatic. Undergoes enterohepatic recirculation
Identifiers
CAS Registry Number	57132-53-3 59209-40-4
ATC code	M01AB14
PubChem	CID 4921
ChemSpider	4752^Y
UNII	FV919079LU^Y
ChEBI	CHEBI:76263
Synonyms	3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate
Chemical data
Formula	C₄₆H₅₈Cl N₅O₈
Molecular mass	844.43442 g/mol
SMILES Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCCN4CCN(CC4)CCCOC(=O)CCC(C(=O)N(CCC)CCC)NC(=O)c5ccccc5
InChI InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55) ^Y Key:PTXGHCGBYMQQIG-UHFFFAOYSA-N ^Y
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Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,^[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

References

↑ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.

Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)

Pyrazolones /
Pyrazolidines

Salicylates

Acetic acid derivatives
and related substances

Oxicams

Propionic acid derivatives
(profens)

Alminoprofen
Benoxaprofen^†
Carprofen^‡
Dexibuprofen
Dexketoprofen
Fenbufen
Fenoprofen
Flunoxaprofen
Flurbiprofen
Ibuprofen^#
Ibuproxam
Indoprofen^†
Ketoprofen
Loxoprofen
Miroprofen
Naproxen
Oxaprozin
Pirprofen
Suprofen
Tarenflurbil
Tepoxalin^‡
Tiaprofenic acid
Vedaprofen^‡
COX-inhibiting nitric oxide donator: Naproxcinod

N-Arylanthranilic acids
(fenamates)

Coxibs

Other

Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

Index of muscle

Description	Anatomy head neck arms chest and back diaphragm abdomen genital area legs Muscle tissue Physiology connective tissue

Disease	Myopathy Soft tissue Connective tissue Congenital abdomen muscular dystrophy Neoplasms and cancer Injury Symptoms and signs eponymous

Treatment	Procedures Drugs anti-inflammatory muscle relaxants