Proamanullin

Proamanullin

Names
Other names 2-L-Proline-3-isoleucine-alpha-amanitin
Identifiers
CAS Registry Number	54532-46-6
Jmol-3D images	Image
PubChem	171350
SMILES O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(N)=O)C(N5[C@H]4CCC5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC([C@@]([C@@H](C)CC)([H])N[C@@]4=O)=O
Properties
Chemical formula	C39H54N10O11S
Molar mass	870.97 g/mol
Appearance	Colorless, odorless
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms.

Toxicology

Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).^[1]

See also

• Mushroom poisoning

References

External links

• Amatoxins REVISED

Poisoning from Amanitas sect. Amanita Species A. albocreata A. crenulata A. farinosa A. frostiana A. gemmata A. multisquamosa A. muscaria A. pantherina A. porphyria A. regalis A. strobiliformis A. xanthocephala Compounds Toxins: Ibotenic Acid Muscimol Other compounds: Muscarine Muscazone Amavadine sect. Phalloidea Species Destroying angels A. bisporigera A. exitialis A. magnivelaris A. ocreata A. verna A. virosa A. virosiformis Other members A. arocheae A. phalloides A. subjunquilea Compounds Amatoxins Amanitins alpha- beta- gamma- epsilon- Amanullin Amanullinic acid Amaninamide Amanin Proamanullin Phallotoxins Phallacidin Phallacin Phallisacin Phallisin Phalloidin Phalloin Prophalloin Other compounds Antamanide Phallolysin Toxophallin sect. Lepidella Species A. nauseosa A. proxima A. smithiana A. sphaerobulbosa A. thiersii Compounds Allenic norleucine (2-amino-4,5-hexadienoic acid) Propargylglycine sect. Validae Species A. rubescens (A. amerirubescens nom. prov.) Compounds Rubescenslysin