Polythiazide

Polythiazide
Systematic (IUPAC) name


6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601101
Identifiers
CAS Registry Number	346-18-9^Y
ATC code	C03AA05
PubChem	CID 4870
ChemSpider	4704^N
UNII	36780APV5N^N
KEGG	D00657^N
ChEMBL	CHEMBL1587^N
Chemical data
Formula	C₁₁H₁₃Cl F₃N₃O₄S₃
Molecular mass	439.88 g/mol
N (what is this?) (verify)

Polythiazide is a thiazide diuretic.^[1]^[2] A diuretic is any substance that promotes the production of urine.

References

↑ O'Brien, E. T.; MacKinnon, J. (1972). "Propranolol and polythiazide in treatment of hypertension". British heart journal 34 (10): 1042–1044. doi:10.1136/hrt.34.10.1042. PMC 458544. PMID 5086971.
↑ Monroy, A.; Plata, C.; Hebert, S. C.; Gamba, G. (2000). "Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: A new model for ions and diuretics interaction". American journal of physiology. Renal physiology 279 (1): F161–F169. PMID 10894798.

Symporter inhibitors

Sodium chloride	thiazide: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide Hydroflumethiazide Methyclothiazide Polythiazide Trichlormethiazide other: Chlorthalidone Metolazone

Sodium, potassium, chloride	Bumetanide Furosemide

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozoline Muzolimine Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epithiazide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spironolactone^# Eplerenone Potassium canrenoate Canrenone

Other

Index of the circulatory system

Description	Anatomy Arteries head and neck arms chest abdomen legs Veins head and neck arms chest abdomen and pelvis legs Development Cells Physiology proteins

Disease	Congenital Neoplasms and cancer Lymphatic vessels Injury Vasculitis Other Symptoms and signs eponymous

Treatment	Procedures Drugs beta blockers channel blockers diuretics nonsympatholytic vasodilatory antihypertensives peripheral vasodilators renin–angiotensin system sympatholytic antihypertensives vasoprotectives