Poly(ADP-ribose) glycohydrolase
| Poly(ADP-ribose) glycohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.143 | ||||||||
| CAS number | 9068-16-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- hydrolyses poly(ADP-ribose) at glycosidic (1-2') linkage of ribose-ribose bond to produce free ADP-ribose
Specific to (1-2') linkage of ribose-ribose bond of poly(ADP-ribose).
References
- ↑ Miwa, M. and Sugimura, T. (1971). "Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-ribose) by a calf thymus extract". J. Biol. Chem. 246: 6362–6364. PMID 4331388.
- ↑ Lin, W., Ame, J.C., Aboul-Ela, N., Jacobson, E.L. and Jacobson, M.K. (1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". J. Biol. Chem. 272: 11895–11901. doi:10.1074/jbc.272.18.11895. PMID 9115250.
External links
- Poly(ADP-ribose) glycohydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)