Pol (HIV)
Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene.
Products of pol include:
Reverse transcriptase
Main article: Reverse transcriptase
Common to all retroviruses, this enzyme transcribes the viral RNA into double-stranded DNA.
Integrase
Main article: Integrase
This enzyme integrates the DNA produced by reverse transcriptase into the host's genome.
Protease
Main article: HIV-1 protease
A protease is any enzyme that cuts proteins into segments. HIV's gag and pol genes do not produce their proteins in their final form, but as larger combination proteins; the specific protease used by HIV cleaves these into separate functional units. Protease inhibitor drugs block this step.
See also
External links
- Gene Products, pol at the US National Library of Medicine Medical Subject Headings (MeSH)
- pol Gene Products, Human Immunodeficiency Virus at the US National Library of Medicine Medical Subject Headings (MeSH)
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