Pirquinozol

Pirquinozol
Systematic (IUPAC) name
2-(hydroxymethyl)pyrazolo[1,5-c]quinazolin-5(6H)-one
Clinical data
  • Uncontrolled
Oral
Identifiers
65950-99-4
None
PubChem CID 47783
ChemSpider 11317704
UNII D16HG4V2UC Yes
KEGG D05516
Chemical data
Formula C11H9N3O2
215.21 g/mol

Pirquinozol (SQ-13,847) is a drug which was investigated as an antiallergen and antiasthmatic agent in the early 1980s but was never marketed.[1][2][3] Notably, pirquinozol is not an antihistamine, though it does block the release of histamine evoked by allergens, and it does not bind to β-adrenergic receptors either.[1]

References

  1. ↑ 1.0 1.1 Free CA, Hall LE (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. II. Activity in vitro". The Journal of Pharmacology and Experimental Therapeutics 213 (3): 437–40. PMID 6162946.
  2. ↑ Casey FB, Abboa-Offei BE, Marretta J (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. I. Activity in vivo". The Journal of Pharmacology and Experimental Therapeutics 213 (3): 432–6. PMID 7205610.
  3. ↑ Casey FB, Abboa-Offei BE (June 1983). "Anti-allergic properties of pirquinozol (SQ 13,847) an orally effective agent. Evaluation in an anti-IgE-induced pulmonary function model in rats". The Journal of Pharmacy and Pharmacology 35 (6): 394–6. doi:10.1111/j.2042-7158.1983.tb02967.x. PMID 6135784.