Pioneer Plague
Pioneer Plague is a game designed by Bill Williams for the Commodore Amiga computer system and released in 1988.
It was one of the few games to use the Hold-And-Modify display mode of the Amiga for in-game graphics, allowing thousands of colors to be displayed at one time. It may have been the first commercial game to do so.
Pioneer Plague received good scores from the computer game press.[1]