Pilomatricoma
| Pilomatricoma | |
|---|---|
 Micrograph of a pilomatricoma showing the characteristic "ghost" cells (anucleate squamous cells), benign viable squamous cells and multi-nucleated giant cells. H&E stain. | |
| Classification and external resources | |
| ICD-10 | D23 |
| DiseasesDB | 32128 |
| eMedicine | article/1058965 |
Pilomatricoma, also known as a calcifying epithelioma of Malherbe,[1] Malherbe calcifying epithelioma, and Pilomatrixoma, is a benign skin tumor derived from the hair matrix.[2]:670[3]
Histologic features
Pilomatricomas consist of anucleate squamous cells (called "ghost cells"), benign viable squamous cells and multi-nucleated giant cells. The presence of calcifications is common.
Pathogenesis
Pilomatricoma is associated with high levels of beta-catenin caused by either a mutation in the APC gene or beta-catenin gene. These high levels of beta-catenin can aid cell proliferation, inhibit cell death, and ultimately lead to cancer.[4]
See also
- Malignant pilomatricoma
- List of cutaneous conditions
- List of cutaneous neoplasms associated with systemic syndromes
References
- ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ↑ Levy J, Ilsar M, Deckel Y, Maly A, Anteby I, Pe'er J (2008). "Eyelid pilomatrixoma: a description of 16 cases and a review of the literature". Surv Ophthalmol 53 (5): 526–35. doi:10.1016/j.survophthal.2008.06.007. PMID 18929763.
- ↑ Hassanein AM, Glanz SM, Kessler HP, Eskin TA, Liu C (2003). "beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst". Am J Clin Pathol (5):732-6. PMID 14608900.
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