Picornavirus internal ribosome entry site (IRES)
| Picornavirus internal ribosome entry site (IRES) | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of IRES_Picorna | |
| Identifiers | |
| Symbol | IRES_Picorna |
| Rfam | RF00229 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | 0043022 |
| SO | 0000243 |
This family represents the Picornavirus internal ribosome entry site (IRES). IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.[1][2]
References
- ↑ Ray, PS; Das S (2002). "La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA". Nucleic Acids Res 30 (20): 4500–4508. doi:10.1093/nar/gkf583. PMC 137146. PMID 12384597.
- ↑ Liu, Z; Carthy CM; Cheung P; Bohunek L; Wilson JE; McManus BM; Yang D (1999). "Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants". Virology 265 (2): 206–217. doi:10.1006/viro.1999.0048. PMID 10600593.