Phosphatidyl ethanolamine methyltransferase
Phosphatidyl ethanolamine methyltransferase (or Phosphatidylethanolamine N-methyltransferase) also known as PEMT is an enzyme which in humans is encoded by the PEMT gene.[1][2][3]
Function
The PEMT enzyme converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17.[3]
See also
References
- ↑ Walkey CJ, Shields DJ, Vance DE (January 1999). "Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2". Biochim. Biophys. Acta 1436 (3): 405–12. doi:10.1016/s0005-2760(98)00147-7. PMID 9989271.
- ↑ Vance DE, Li Z, Jacobs RL (November 2007). "Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology". J. Biol. Chem. 282 (46): 33237–41. doi:10.1074/jbc.R700028200. PMID 17881348.
- ↑ 3.0 3.1 "Entrez Gene: PEMT".
Further reading
- Zemunik T, Boban M, Lauc G et al. (2009). "Genome-wide Association Study of Biochemical Traits in Korčula Island, Croatia". Croat. Med. J. 50 (1): 23–33. doi:10.3325/cmj.2009.50.23. PMC 2657564. PMID 19260141.
- Mostowska A, Hozyasz KK, Wojcicki P et al. (2009). "Associations of folate and choline metabolism gene polymorphisms with orofacial clefts". J. Med. Genet. 47 (12): 809–15. doi:10.1136/jmg.2009.070029. PMID 19737740.
- Song J, da Costa KA, Fischer LM et al. (2005). "Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)". FASEB J. 19 (10): 1266–71. doi:10.1096/fj.04-3580com. PMC 1256033. PMID 16051693.
- Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA (2009). "Genetic variants in phosphatidylethanolamine N-methyltransferase (PEMT) and methylenetetrahydrofolate dehydrogenase (MTHFD1) influence biomarkers of choline metabolism when folate intake is restricted". J Am Diet Assoc 109 (2): 313–8. doi:10.1016/j.jada.2008.10.046. PMC 2655101. PMID 19167960.
- da Costa KA, Kozyreva OG, Song J et al. (2006). "Common genetic polymorphisms affect the human requirement for the nutrient choline". FASEB J. 20 (9): 1336–44. doi:10.1096/fj.06-5734com. PMC 1574369. PMID 16816108.
- Saito A, Kawamoto M, Kamatani N (2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". J. Hum. Genet. 54 (6): 317–23. doi:10.1038/jhg.2009.31. PMID 19343046.
- Vance DE, Walkey CJ, Cui Z (1997). "Phosphatidylethanolamine N-methyltransferase from liver". Biochim. Biophys. Acta 1348 (1–2): 142–50. doi:10.1016/s0005-2760(97)00108-2. PMID 9370326.
- Dong H, Wang J, Li C et al. (2007). "The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population". J. Hepatol. 46 (5): 915–20. doi:10.1016/j.jhep.2006.12.012. PMID 17391797.
- Resseguie M, Song J, Niculescu MD et al. (2007). "Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes". FASEB J. 21 (10): 2622–32. doi:10.1096/fj.07-8227com. PMC 2430895. PMID 17456783.
- Li H, Zhang H, Liu L et al. (2009). "No association of the rs4646396 SNP in the PEMT locus with schizophrenia in a Chinese case-control sample". Psychiatry Res 169 (2): 176–7. doi:10.1016/j.psychres.2008.11.004. PMID 19647326.
- Caudill MA, Dellschaft N, Solis C et al. (2009). "Choline Intake, Plasma Riboflavin, and the Phosphatidylethanolamine N-Methyltransferase G5465A Genotype Predict Plasma Homocysteine in Folate-Deplete Mexican-American Men with the Methylenetetrahydrofolate Reductase 677TT Genotype". J. Nutr. 139 (4): 727–33. doi:10.3945/jn.108.100222. PMC 2714377. PMID 19211833.
- Shields DJ, Lingrell S, Agellon LB et al. (2005). "Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase". J. Biol. Chem. 280 (29): 27339–44. doi:10.1074/jbc.M504658200. PMID 15927961.
- Liu Y, Zhang H, Ju G et al. (2007). "A study of the PEMT gene in schizophrenia". Neurosci. Lett. 424 (3): 203–6. doi:10.1016/j.neulet.2007.07.038. PMID 17720317.
- Shields DJ, Altarejos JY, Wang X et al. (2003). "Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase". J. Biol. Chem. 278 (37): 35826–36. doi:10.1074/jbc.M306308200. PMID 12842883.
- Xu X; Gammon MD; Zeisel SH; Wetmur, J. G.; Teitelbaum, S. L.; Bradshaw, P. T.; Neugut, A. I. et al. (2008). "Choline metabolism and risk of breast cancer in a population-based study". FASEB J. 22 (6): 2045–52. doi:10.1096/fj.07-101279. PMC 2430758. PMID 18230680.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tessitore L, Marengo B, Vance DE et al. (2003). "Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas". Oncology 65 (2): 152–8. doi:10.1159/000072341. PMID 12931022.
- Jun DW, Han JH, Jang EC et al. (2009). "Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans". Eur J Gastroenterol Hepatol 21 (6): 667–72. doi:10.1097/MEG.0b013e3283196adc. PMID 19262398.
- Chen SN, Cilingiroglu M, Todd J et al. (2009). "Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis". BMC Med. Genet. 10: 111. doi:10.1186/1471-2350-10-111. PMC 2775733. PMID 19878569.
External links
- Phosphatidylethanolamine N-Methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.