Perminder Sachdev

Perminder Sachdev, AM, MD, PhD, FRANZCP (born 1956) is a neuropsychiatrist based in Australia. He is the Scientia Professor of Neuropsychiatry at the University of New South Wales (UNSW), Australia, the director of the Centre for Healthy Brain Ageing (CHeBA), UNSW, and the Clinical Director of the Neuropsychiatric Institute (NPI) at the Prince of Wales Hospital, Sydney, Australia [1].

Early life

Dr Sachdev was born in Ludhiana, India and went to school in Solan, in the foot-hills of the Himalayas [2]. He received his MBBS from the All-India Institute of Medical Sciences (AIIMS) in 1978, his MD in psychiatry from AIIMS in 1981, and his PhD in psychiatry from UNSW in 1991 [3]. He became a Fellow of the Royal Australian & New Zealand College of Psychiatrists (FRANZCP) in 1985 [3].

Clinical and research achievements

Dr Sachdev is the Clinical Director of the NPI at the Prince of Wales Hospital [4]. He has played a leading role in the development of higher training in Neuropsychiatry through his leadership of the International Neuropsychiatric Association (INA), and the Neuropsychiatry Section of the RANZCP [5]. The major contribution of the NPI to psychiatric research has been in the field of Movement disorders, such as drug-induced Akathisia, tardive dystonia, Neuroleptic malignant syndrome, Tourette Syndrome, golfer's cramp and Psychomotor retardation in Melancholia [6]. In particular, akathisia and its subtypes were characterised, including the development of a rating scale and research diagnostic criteria [7].

Other work has been in the areas of late-onset Schizophrenia [8] and secondary schizophrenia (including head injuries and schizophrenia-like psychosis) [9]. Dr Sachdev published the first negative study of Transcranial Magnetic Stimulation (TMS) for depression [10], the first TMS treatment study of Obsessive Compulsive Disorder (OCD) [11], and the first study that examined the effect of different frequencies of TMS on an animal model of depression [12].

Dr Sachdev's early research was in the field of Transcultural psychiatry, including descriptions of Maori ethnopsychiatric constructs such as mana-tapu-noa and whakama [13].

Since 1997, Dr Sachdev's major area of research has been cognitive disorders [14]. He is currently directing a number of longitudinal, community-based studies of brain ageing, including the Sydney Memory and Ageing Study (MAS), the Older Australian Twins Study (OATS), the Sydney Centenarian Study (SCS), and the Sydney Stroke Study (SSS) [15]. He is also a collaborator on one of the largest community based studies of brain imaging: the Australian PATH Through Life Study [16]. Sachdev has contributed to the diagnosis of dementia as a member of the Neurocognitive Disorders Workgroup for the DSM-5 [17]. He has also contributed to the field of epilepsy research as a member of the Task Force of the International League Against Epilepsy (ILAE) Neuropsychobiology Commission [18].

Honours and awards

In 2011, Dr Sachdev was made a Member of the Order of Australia (AM) for "services to medical research in the field of neuropsychiatry, as a clinician and academic, and to professional associations at a national and international level" [19]. He has received numerous other awards, including the NSW Scientist of the Year in Biomedical Sciences (2010) [20] and the Organon Senior Research Award, Royal Australian & New Zealand College of Psychiatrists (RANZCP) for the best research by an Australian or New Zealand psychiatrist in the previous five years (1995) [21]. He occupied the first chair of Neuropsychiatry in Australia [22].

Dr Sachdev is a Founding Executive committee member of the Tourette Syndrome Association of Australia [23]. He was elected President (2004–2006) of the International Neuropsychiatric Association [24]. Dr Sachdev was international advisor to the Psychosurgery Review Committee of the American Neurosurgical Society and a member of the F1000 Reports advisory board. He has served on the editorial board of a number of international peer-reviewed journals, including the American Journal of Geriatric Psychiatry, Neuropsychiatric Disorders and Treatment, Acta Neuropsychiatrica and Current Opinion in Psychiatry [25].

Bibliography

Dr Sachdev is the author/editor of 5 books, first author for 31 and co-author for 10 book chapters, and has been involved as first- or co-author for over 278 papers in refereed journals [26]. His work has received over 5000 citations to date [27].

External links

BARP http://psych.med.unsw.edu.au/psychweb.nsf/page/Brainage

UNSW Research Gateway http://research.unsw.edu.au/people/scientia-professor-perminder-singh-sachdev

References

[1] UNSW Research Gateway, http://research.unsw.edu.au/people/scientia-professor-perminder-singh=sachdev. Retrieved 4 July 2011.

[2] 'Perminder Singh Sachdev' in Who's Who in Australia 2011. Crown Content Pty Ltd; Melbourne, 2010. Accessed on-line: http://crownweb.crowncontent.com.au/ww/. Retrieved 6 July 2011.

[3] 'Perminder Singh Sachdev' in Who's Who in the World (24th ed.) 2007; UNSW Research Gateway, http://research.unsw.edu.au/people/scientia-professor-perminder-singh-sachdev. Retrieved 4 July 2011.

[4] 'Perminder Singh Sachdev' in Who's Who in Australia 2011. Crown Content Pty Ltd; Melbourne, 2010. Accessed on-line: http://crownweb.crowncontent.com.au/ww/. Retrieved 6 July 2011; UNSW Research Gateway, http://research.unsw.edu.au/people/scientia-professor-perminder-singh-sachdev. Retrieved 4 July 2011; Herbertson L, Rice M, ‘Our Local Heroes Queen’s Birthday Honours 2011’, Wentworth Courier, 15 June 2011, 6; Neuropsychiatric Institute, http://web.med.unsw.edu.au/npi/About/index.htm. Retrieved 4 July 2011.

[5] The Queen's Birthday 2011 Honours List, http://www.gg.gov.au/res/file/2011/honours/qb11/Media%20Notes%20AM%20(M-Z)%20(final).pdf, 68. Retrieved 4 July 2011.

[6] Sachdev PS. Clinical characteristics of 15 patients with tardive dystonia. Am J Psychiatry 1993; 150:498 500; Sachdev PS. Risk factors for tardive dystonia: A case control comparison with tardive dyskinesia. Acta Psychiatr Scand 1993; 88:98 103; Sachdev PS. Tardive and chronically recurrent oculogyric crises. Mov Disord 1993: 1:93–97; Sachdev P. Tardive blepharospasm. Mov Disorders 1998; 13(6):947–951; Sachdev PS. Psychoactive drug use in an institution for intellectually handicapped persons. Med J Australia 1991; 155:75 79; Kruk J, Sachdev P, Singh S. Neuroleptic-induced respiratory dyskinesia. J Neuropsych Clin Neurosci 1995; 7(2):223–229; Sachdev P, Mason C, Hadzi-Pavlovic H. A case controlled study of neuroleptic malignant syndrome. Am J Psychiatry 1997; 154:1156–1158; Sachdev PS. A rating scale for neuroleptic malignant syndrome (NMS). Psychiatry Research 2005; 135:249–256; Chee K, Sachdev P. The clinical features of Tourette’s Disorder: an Australian study using a structured interview schedule. Aust NZ J Psychiatry 1994; 28:313–318; Chee K-Y, Sachdev P. A controlled study of sensory tics in Gilles de la Tourette syndrome and obsessive-compulsive disorder using a structured interview. J Neurol Neurosurg Psychiatry 1997; 62; 188–192; Sachdev P, Chee K, Aniss A. The audiogenic startle reflex in Tourette's Syndrome. Biol Psychiatry 1997; 41:796–803; Sachdev PS. Golfers' cramp: Clinical characteristics and evidence against it being an anxiety disorder. Mov Disord 1992; 4:326 332; Sachdev PS, Aniss AM. Slowness of movement in melancholic depression. Biol Psychiatry 1994; 35:253–262.

[7] Sachdev P, Chee K-Y. Pharmacological characterisation of tardive akathisia. Biol Psychiatry 1990; 28:809–818; Sachdev P, Loneragan C. The present status of akathisia, J Nerv Ment Dis 1991; 179:381–391; Sachdev P, Loneragan C. Low dose apomorphine challenge in acute neuroleptic-induced akathisia. Neurology 1993; 43:544–547; Sachdev P, Kruk J. Clinical characteristics and predisposing factors in acute drug induced akathisia. Arch Gen Psychiatry 1994; 51:963–974; Sachdev P. Research diagnostic criteria for drug-induced akathisia: conceptualisation, rationale, and proposal. Psychopharmacology (Berl) 1994; 114:181–186; Sachdev P. A rating scale for acute drug-induced akathisia: development, reliability and validity. Biol Psych 1994; 35(4):263–271; Sachdev P. The epidemiology of drug-induced akathisia, I: acute akathisia. Schizophr Bull 1995; 21:431–449; Sachdev P. The epidemiology of drug-induced akathisia. II: chronic, tardive, and withdrawal akathisias. Schizophr Bull 1995; 21:451–461; Sachdev P. The development of the concept of akathisia: a historical overview. Schizophr Res 1995; 16:33–45; Sachdev PS. Akathisia and Restless Legs. New York: Cambridge University Press, 1995; Sachdev P, Hume F, Toohey P, Doutney C. Negative symptoms, cognitive dysfunction, tardive akathisia and tardive dyskinesia. Acta Psychiatr Scand 1996; 93(6):451–459; Sachdev P. Animal models of drug-induced akathisia. In LeDoux MS (Ed). Animal models of movement disorders. Academic Press, Elsevier Inc: USA, 2004:745–753; Sachdev P. Acute and tardive drug-induced akathisia. In Sethi KD (Ed). Drug-induced Movement Disorders. Neurological Disease and Therapy Series. Macel Dekker, New York, 2005:129–164.

[8] Brodaty H, Sachdev P, Rose N, Rylands K, Prenter L. Schizophrenia with onset after age 50 years. 1: Phenomenology and risk factors. Br J Psychiatry 1999; 175: 410–415; Sachdev P, Brodaty H, Rose N, Cathcart S. Schizophrenia with onset after age 50 years. 2: A neurological, neuropsychological and MRI investigation. Br J Psychiatry 1999; 175:416–421.

[9] Sachdev P, Smith JS, Cathcart S. Schizophrenia-like psychosis following traumatic brain injury: a chart-based descriptive and case-control study. Psychological Medicine 2001; 31(2):231–239.

[10] Loo C, Mitchell P, Sachdev P, et al. Double-blind controlled investigation of transcranial magnetic stimulation for the treatment of resistant major depression. American Journal of Psychiatry 1999; 156(6):946–948.

[11] Sachdev PS, Loo CK, Mitchell PB, McFarquhar TF, Malhi GS. Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation. Psychological Medicine 2007; 37:1645–1650.

[12] Hargreaves GA, McGregor IS, Sachdev PS. Chronic repetitive transcranial magnetic stimulation is antidepressant but not anxiolytic in rat models of anxiety and depression. Psychiatry Research 2005; 137:113–121.

[13] Sachdev PS, Shukla A. Epidemic Koro syndrome in India. The Lancet 1982; ii: 1161; Sachdev PS. Koro epidemic in northeast India. Aust N Z J Psychiatry 1985; 19(4):433 36; Sachdev PS. Psychiatric illness in the New Zealand Maori. Aust NZ J Psychiatry 1989; 23:529 541; Sachdev PS. Mana, Tapu, Noa: Maori cultural constructs with medical and psycho social relevance. Psychol Med 1989; 19:959 970; Sachdev PS. Maori elder-patient relationship as a therapeutic paradigm. Psychiatry 1989; 53:393 403; Sachdev PS. Behavioural factors affecting physical health of the New Zealand Maori. Soc Sci Med 1990; 30(4):431 440; Sachdev PS. Whakama: culturally determined behaviour in the New Zealand Maori. Psychol Med 1990; 20:433 444; Sachdev PS. Personality development in traditional Maori society and the impact of modernisation. Psychiatry 1990; 53 (3):289 303; Sachdev PS. Overview: Mental health and illness of the New Zealand Maori. Transcultural Psychiatric Research Review 1990; 27:85 111.

[14] 'New insights into brain functions', Southern Courier, 15 February 2011, 28; 'All in the mind: On the couch: Perminder Sachdev and Norman Doidge’, ABC Radio National, 25 September 2010: http://www.abc.net.au/rn/allinthemind/stories/2010/3016990.htm. Retrieved 29 June 2011; Hussein S, ‘Brains, Minds, Hearts And Souls’, New Matilda, 20 May 2010: http://newmatilda.com/2010/05/20/brains-minds-hearts-souls. Retrieved 29 June 2011; Turney D, ‘Think again: reinterpreting the brain’, The Sydney Morning Herald, 1 April 2010, 19; ‘Mirror neuron systems offer exciting prospects’, The Hindu, 7 September 2009, 11; Williams D, ‘Mind over mirror’, Time Australia, 30 October 2006, 50–51; Pountney M, ‘Brain secrets take two to untangle’, Herald-Sun, 30 August 2006, 26; ‘Brains are ageing faster’, The Daily Telegraph, 6 April 2006, 13; Williams D, ‘Boosting brain fitness’, Time Australia, 20 February 2006, 57; Miles J, ‘Solving a brain teaser’, Herald-Sun, 25 January 2006, 35; ‘Keep the brain active and repel dementia’, Daily Telegraph, 25 January 2006, 21; Skatssoon J, ‘Many sides to depression’, The Sydney Morning Herald, 25 August 2005, 10.

[15] Wen W, Sachdev P, Li JJ, Chen X, Anstey KJ White matter hyperintensities in the forties: Their prevalence and topography in an epidemiological sample aged 44–48. Human Brain Mapping 2009; 30: 1155–1167; Jorm AF, Anstey KJ, Christensen H, de Plater G, Kumar R, Wen W, Sachdev P. MRI hyperintensities and depressive symptoms in a community sample of 60–64 year olds. Am J Psychiatry 2005; 162:699–704; Kumar R, Parslow RA, Jorm AF, Rosenman SJ, de Plater G, Maller JJ, Meslin C, Anstey KJ, Christensen H, Sachdev PS. Clinical and neuroimaging correlates of mild cognitive impairment in a middle-aged community sample: the PATH through Life 60+ study. Dementia & Geriatric Cognitive Disorders 2006; 21:44–50; Wen W, Sachdev PS, Chen X, Anstey K. Gray matter reduction is correlated with white matter hyperintensity volume: A voxel-based morphometric study in a large epidemiological sample. NeuroImage 2006; 29:1031–1039; Cherbuin N, Windsor TD, Anstey KJ, Maller J, Meslin C, Sachdev PS. Hippocampal volume is positively associated with behavioural inhibition (BIS) in a large community-based sample of mid-life adults: the PATH through life study. Social Cognitive and Affective Neuroscience 2008; 3: 262–269; Cherbuin N, Reglade-Meslin C, Kumar R, Jacomb P, Easteal S, Christensen H, Sachdev P, Anstey KJ. Risk factors of transition from normal cognition to mild cognitive disorder: The PATH through life study. Dementia & Geriatric Cognitive Disorders 2009; 28: 47–55.

[16] Brain and Ageing Research Program, http://psych.med.unsw.edu.au/psychweb.nsf/page/Brainage. Retrieved 4 July 2011; Sachdev PS, Lammel A, Trollor JN, Lee T, Wright MJ, Ames D, Wen W, Martin NG, Brodaty H, Schofield PR, and the OATS Research Team. A comprehensive neuropsychiatric study of elderly twins: The Older Australian Twins Study. Twin Research and Human Genetics 2009; 12:573–582; Sachdev PS, Lee T, Lammel A, Crawford J, Trollor J, Wright M, Brodaty H, Ames D, Martin N. Cognitive functioning in older twins: The Older Australian Twins Study. Australasian Journal on Ageing 2011 (in press); Lee T, Mosting MA, Henry JD, Trollor JN, Lammel A, Ames D, Martin NG, Wright MJ, Sachdev PS. Genetic Influences on Five Measures of Processing Speed and Their Covariation with General Cognitive Ability in the Elderly: The Older Australian Twins Study. Behavioural Genetics 2011 (in press); Sachdev PS, Brodaty H, Valenzuela MJ, Lorentz L, Looi JCL, Wen W, Zagami A. The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients. Neurology 2004; 62:912–919; Roman GC, Sachdev P, Royall DR, Bullock RA, Orgogozo J-M, Lopezx-Pousa S, Arizaga R, Wallin A. Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia. [Proceedings of the First Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG 2003)]. Journal of Neurological Sciences 2004; 226:81–87; Sachdev P, Valenzuela M, Wang XL, Looi JCL, Brodaty H. Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals. Neurology 2002; 58:1539–1541; Wen W, Sachdev P, Shnier R, Brodaty H. Effect of white matter hyperintensities on cortical cerebral blood volume using perfusion MRI. NeuroImage 2004; 21(4):1350–1356; Sachdev P, Wen W, Chen X, Brodaty H. Progression of white matter hyperintensities in elderly individuals over 3 years. Neurology 2007; 68:214–222 (PMID 17224576); Withall A, Brodaty H, Altendorf A, Sachdev P. A longitudinal study examining the independence of apathy and depression after stroke: The Sydney Stroke Study. International Psychogeriatrics 2011; 23: 264–273; Brodaty H, Sachdev P, Withall A, Altendorf A, Valenzuela M, Lorentz L. Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke: the Sydney Stroke Study. Psychological Medicine 2005; 35: 1707–1716; Slavin MJ, Brodaty H, Kochan NA, Trollor JN, Draper B, Sachdev PS. Prevalence and predictors of ‘subjective cognitive complaints’ in the Sydney Memory and Ageing Study. American Journal of Geriatric Psychiatry 2010; 18: 701–710.

[17] Neurocognitive Disorders Workgroup, American Psychiatric Association DSM-5 Development, http://www.dsm5.org/MeetUs/Pages/NeurocognitiveDisorders.aspx. Retrieved 4 July 2011.

[18] The Queen's Birthday 2011 Honours List, http://www.gg.gov.au/res/file/2011/honours/qb11/Media%20Notes%20AM%20(M-Z)%20(final).pdf, 68. Retrieved 4 July 2011.

[19] Herbertson L, Rice M, 'Our Local Heroes Queen's Birthday Honours 2011', Wentworth Courier, 15 June 2011, 6; 'Queen's Birthday Honours Part 1 of 2', The Australian, 13 June 2011, 8.

[20] 'At University of NSW – NSW Scientist of the Year Awards', Southern Courier, 12 October 2010, 29.

[21] 'Perminder Singh Sachdev' in Who's Who in Australia 2011. Crown Content Pty Ltd; Melbourne, 2010. Accessed on-line: http://crownweb.crowncontent.com.au/ww/. Retrieved 6 July 2011; The Queen's Birthday 2011 Honours List, http://www.gg.gov.au/res/file/2011/honours/qb11/Media%20Notes%20AM%20(M-Z)%20(final).pdf, 68. Retrieved 4 July 2011.

[22] The Queen's Birthday 2011 Honours List, http://www.gg.gov.au/res/file/2011/honours/qb11/Media%20Notes%20AM%20(M-Z)%20(final).pdf, 68. Retrieved 4 July 2011.

[23] Herbertson L, Rice M, 'Our Local Heroes Queen's Birthday Honours 2011', Wentworth Courier, 15 June 2011, 6; 'Perminder Singh Sachdev' in Who's Who in Australia 2011. Crown Content Pty Ltd; Melbourne, 2010. Accessed on-line: http://crownweb.crowncontent.com.au/ww/. Retrieved 6 July 2011.

[24] 'Perminder Singh Sachdev' in Who's Who in Australia 2011. Crown Content Pty Ltd; Melbourne, 2010. Accessed on-line: http://crownweb.crowncontent.com.au/ww/. Retrieved 6 July 2011.

[25] 'Perminder Singh Sachdev' in Who's Who in Australia 2011. Crown Content Pty Ltd; Melbourne, 2010. Accessed on-line: http://crownweb.crowncontent.com.au/ww/. Retrieved 6 July 2011; Current Opinion in Psychiatry Editorial Board, http://journals.lww.com/co-psychiatry/pages/editorialboard.aspx. Retrieved 4 July 2011.

[26] UNSW Research Gateway, http://research.unsw.edu.au/people/scientia-professor-perminder-singh-sachdev/publications. Retrieved 4 July 2011; ‘Perminder S. Sachdev’ in Scopus, http://www.scopus.com/hirsch/author.url?accessor=authorProfile&auidList=7102284091&authorName=Sachdev%2c+Perminder+S.&origin=AuthorProfile&txGid=a6j15ADkhS6B05YtI-83c7G%3a15. Retrieved 5 July 2011.

[27] 'Perminder S. Sachdev' in Scopus, http://www.scopus.com/hirsch/author.url?accessor=authorProfile&auidList=7102284091&authorName=Sachdev%2c+Perminder+S.&origin=AuthorProfile&txGid=a6j15ADkhS6B05YtI-83c7G%3a15. Retrieved 5 July 2011. Note Scopus only counts citations for articles produced from 1996 onwards. For additional articles see also: ‘Perminder Sachdev’ in ISI Web of Science Citation Report, http://apps.isiknowledge.com/CitationReport.do?product=WOS&search_mode=CitationReport&SID=S1bbhE3KNHaOfcjA2oN&page=1&cr_pqid=8. Retrieved 5 July 2011. Note Web of Science only includes articles produced from 1992 onwards. Dr Sachdev began publishing articles in 1982.