Periostin
| Periostin, osteoblast specific factor | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | POSTN ; OSF-2; OSF2; PDLPOSTN; PN; periostin | ||||||||||||
| External IDs | OMIM: 608777 MGI: 1926321 HomoloGene: 4730 GeneCards: POSTN Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10631 | 50706 | |||||||||||
| Ensembl | ENSG00000133110 | ENSMUSG00000027750 | |||||||||||
| UniProt | Q15063 | Q62009 | |||||||||||
| RefSeq (mRNA) | NM_001135934 | NM_001198765 | |||||||||||
| RefSeq (protein) | NP_001129406 | NP_001185694 | |||||||||||
| Location (UCSC) | Chr 13: 38.14 – 38.17 Mb | Chr 3: 54.36 – 54.39 Mb | |||||||||||
| PubMed search | |||||||||||||
Periostin is a protein that in humans is encoded by the POSTN gene.[1][2] Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells.[3]
Periostin is a gla domain vitamin K dependent factor.[4]
Clinical significance
In asthma
Periostin is associated with asthma, a fact that is exploited by the experimental asthma medication lebrikizumab.[5]
In cancer
Periostin over-expression was reported in several types of cancer, most frequently in the environment of tumor cells.[3][6] Recent evidence shows that periostin is a component of the extracellular matrix expressed by fibroblasts in normal tissues and stroma of primary tumor. The metastatic colony formation requires the induction of periostin in the foreign stroma by the infiltrating cancer cells. Periostin production is upregulated in lung fibroblasts by either TGF-β2 or TGF-β3, the latter being secreted by infiltrating cancer stem cells (in MMTV-PyMT mouse breast cancer model) [7]
Table: Periostin expression in various cancer cell lines.[8]
| Cell line | Origin | POSTN/ACTB1 |
|---|---|---|
| U2OS | Osteosarcoma | 3.5±1.7 |
| LB96 | Ewing Sarcoma | 0 |
| LB23-1 | Rhabdomyosarcoma | 0.1±0.1 |
| HeLa | Cervical cancer | 3.0±0.4 |
| PA-1 | Ovarian teratocarcinoma | 1.4±0.1 |
| LB37-1 | NSCLC | 2.8±0.6 |
| LB85 | SCLC | 3.4±0.2 |
| LB92 | SCLC | 0.6±0.2 |
| LB1047 | Renal cell carcinoma | 0.8±0.2 |
| BB64 | Renal cell carcinoma | 0.08±0.01 |
| LB108 | Colorectal cancer | 0 |
| MCF7 | Breast Cancer | 0 |
| Hs578T | Breast Cancer | 3693±86 |
| Panc-1 | Pancreatic carcinoma | 0 |
| Capan-1 | Pancreatic carcinoma | 0 |
| Huh-7 | Hepatocarcinoma | 0.3±0.07 |
| LB831 | Bladder carcinoma | 1748±74 |
| MZGC3 | Stomach cancer | 0 |
| A172 | Glioblastoma | 45±4 |
| MZ2 | Melanoma | 2.3±0.7 |
| LB39 | Melanoma | 0.5±0.03 |
| LB2586-7 | Melanoma | 3.4±0.3 |
| LB2201-3 | Melanoma | 4.2±0.4 |
| A375 | Melanoma | 4.7±1.2 |
1 (cDNA POSTN/cDNA ACTB) × 104
References
- ↑ Takeshita S, Kikuno R, Tezuka K, Amann E (Sep 1993). "Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I". Biochem J. 294. ( Pt 1): 271–8. PMC 1134594. PMID 8363580.
- ↑ "Entrez Gene: POSTN periostin, osteoblast specific factor".
- ↑ 3.0 3.1 Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (Sep 2002). "Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility". Cancer Res 62 (18): 5358–64. PMID 12235007.
- ↑ PMID 18450759
- ↑ Corren J, Lemanske RF, Hanania NA et al. (September 2011). "Lebrikizumab treatment in adults with asthma" 365 (12). pp. 1088–98. doi:10.1056/NEJMoa1106469. PMID 21812663.
- ↑ Contié S, Voorzanger-Rousselot N, Litvin J et al. (2011). "Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.". Int. J. Cancer 128 (2): 352–60. doi:10.1002/ijc.25591. PMID 20715172.
- ↑ Malanchi I, Santamaria-Martínez A, Susanto E et al. (2011). "Interactions between cancer stem cells and their niche govern metastatic colonization". Nature 481 (7379): 85–9. doi:10.1038/nature10694. PMID 22158103.
- ↑ Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A. (2007). "Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells.". Molecular Cancer 6 (80): 80. doi:10.1186/1476-4598-6-80. PMC 2222651. PMID 18086302.
Further reading
- Sasaki H, Dai M, Auclair D et al. (2001). "Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas.". Cancer 92 (4): 843–8. doi:10.1002/1097-0142(20010815)92:4<843::AID-CNCR1391>3.0.CO;2-P. PMID 11550156.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dunham A, Matthews LH, Burton J et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Shao R, Bao S, Bai X et al. (2004). "Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.". Mol. Cell. Biol. 24 (9): 3992–4003. doi:10.1128/MCB.24.9.3992-4003.2004. PMC 387763. PMID 15082792.
- Bao S, Ouyang G, Bai X et al. (2004). "Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.". Cancer Cell 5 (4): 329–39. doi:10.1016/S1535-6108(04)00081-9. PMID 15093540.
- Kim CJ, Yoshioka N, Tambe Y et al. (2005). "Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells.". Int. J. Cancer 117 (1): 51–8. doi:10.1002/ijc.21120. PMID 15880581.
- Chang Y, Lee TC, Li JC et al. (2005). "Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma.". Head Neck 27 (10): 873–82. doi:10.1002/hed.20253. PMID 16136586.
- Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Yan W, Shao R (2006). "Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation.". J. Biol. Chem. 281 (28): 19700–8. doi:10.1074/jbc.M601856200. PMID 16702213.
- Försti A, Jin Q, Altieri A et al. (2007). "Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis.". Breast Cancer Res. Treat. 101 (1): 83–93. doi:10.1007/s10549-006-9265-1. PMID 16807673.
- Grigoriadis A, Mackay A, Reis-Filho JS et al. (2007). "Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.". Breast Cancer Res. 8 (5): R56. doi:10.1186/bcr1604. PMC 1779497. PMID 17014703.
- Baril P, Gangeswaran R, Mahon PC et al. (2007). "Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway.". Oncogene 26 (14): 2082–94. doi:10.1038/sj.onc.1210009. PMID 17043657.
- Siriwardena BS, Kudo Y, Ogawa I et al. (2007). "Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer.". Br. J. Cancer 95 (10): 1396–403. doi:10.1038/sj.bjc.6603431. PMC 2360586. PMID 17060937.
- Li JS, Sun GW, Wei XY, Tang WH (2007). "Expression of periostin and its clinicopathological relevance in gastric cancer.". World J. Gastroenterol. 13 (39): 5261–6. PMID 17876898.
- Contié S, Voorzanger-Rousselot N, Litvin J et al. (2010). "Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice.". Calcif. Tissue Int. 87 (4): 341–50. doi:10.1007/s00223-010-9391-y. PMID 20567965.
- Kashyap MK,” et al. (2010). "Overexpression of Periostin and Lumican in Esophageal Squamous Cell Carcinoma.". Cancers. 2 (1): 133–142. doi:10.3390/cancers2010133.