PYGO2

Pygopus family PHD finger 2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2XB1

Identifiers

PYGO2 ; 1190004M21Rik

External IDs

OMIM: 606903 MGI: 1916161 HomoloGene: 44519 GeneCards: PYGO2 Gene

Gene ontology
Molecular function	• protein binding • zinc ion binding • histone binding
Cellular component	• nucleus
Biological process	• in utero embryonic development • kidney development • lens development in camera-type eye • brain development • post-embryonic development • mammary gland development • regulation of mammary gland epithelial cell proliferation • developmental growth • regulation of histone H3-K4 methylation • palate development • canonical Wnt signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000163348

ENSMUSG00000047824

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
154.93 – 154.94 Mb

Chr 3:
89.43 – 89.44 Mb

PubMed search

Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.^[1]^[2]

References

↑ Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (May 2002). "A new nuclear component of the Wnt signalling pathway". Nat Cell Biol 4 (5): 367–73. doi:10.1038/ncb786. PMID 11988739.
↑ "Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila)".

Further reading

Kramps T, Peter O, Brunner E et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.". Cell 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Popadiuk CM, Xiong J, Wells MG et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer". Clin. Cancer Res. 12 (7 Pt 1): 2216–23. doi:10.1158/1078-0432.CCR-05-2433. PMID 16609037.
Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272.
Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer". Int. J. Oncol. 30 (2): 357–63. PMID 17203217.