PTPRN
Receptor-type tyrosine-protein phosphatase-like N is an enzyme that in humans is encoded by the PTPRN gene.[1][2]
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.[2]
Interactions
PTPRN has been shown to interact with SPTBN4.[3]
References
- ↑ Lan MS, Lu J, Goto Y, Notkins AL (August 1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma". DNA Cell Biol 13 (5): 505–14. doi:10.1089/dna.1994.13.505. PMID 8024693.
- ↑ 2.0 2.1 "Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N".
- ↑ Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM et al. (November 2000). "βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001.
Further reading
- Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM et al. (1994). "Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases". J. Immunol. 152 (6): 3183–8. PMID 8144912.
- Solimena M, Dirkx R, Hermel JM, Pleasic-Williams S, Shapiro JA, Caron L et al. (1996). "ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules". EMBO J. 15 (9): 2102–14. PMC 450132. PMID 8641276.
- van den Maagdenberg AM, Olde Weghuis D, Rijss J, van de Wetering RA, Wieringa B, Geurts van Kessel A et al. (1996). "Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker". Cytogenet. Cell Genet. 73 (1–2): 145–8. doi:10.1159/000134327. PMID 8646884.
- Cui L, Yu WP, DeAizpurua HJ, Schmidli RS, Pallen CJ (1996). "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes". J. Biol. Chem. 271 (40): 24817–23. doi:10.1074/jbc.271.40.24817. PMID 8798755.
- Xie J, Zhang B, Lan MS, Notkins AL (1999). "Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN)". Genomics 54 (2): 338–43. doi:10.1006/geno.1998.5583. PMID 9828138.
- Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC et al. (2001). "The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells". Eur. J. Cell Biol. 79 (9): 621–30. doi:10.1078/0171-9335-00095. PMID 11043403.
- Park YS, Kawasaki E, Kelemen K, Yu L, Schiller MR, Rewers M et al. (2001). "Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes". Diabetologia 43 (10): 1293–301. doi:10.1007/s001250051525. PMID 11079748.
- Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM et al. (2001). "βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001.
- Diez J, Park Y, Zeller M, Brown D, Garza D, Ricordi C et al. (2001). "Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen". Diabetes 50 (4): 895–900. doi:10.2337/diabetes.50.4.895. PMID 11289059.
- Ort T, Voronov S, Guo J, Zawalich K, Froehner SC, Zawalich W et al. (2001). "Dephosphorylation of β2-syntrophin and Ca2+/µ-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion". EMBO J. 20 (15): 4013–23. doi:10.1093/emboj/20.15.4013. PMC 149140. PMID 11483505.
- Mikulecký M, Michalková D (2002). "Secular and seasonal cycling of IA2-ab autoantibody in Slovak diabetic children". Biomed. Pharmacother. 55 Suppl 1: 106s–109s. PMID 11774856.
- Miao D, Yu L, Tiberti C, Cuthbertson DD, Rewers M, di Mario U et al. (2002). "ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies". J. Autoimmun. 18 (2): 191–6. doi:10.1006/jaut.2001.0577. PMID 11908951.
- Kawasaki E, Yamaguchi H, Hattori H, Egashira T, Eguchi K (2002). "Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay". Ann. N. Y. Acad. Sci. 958: 241–6. doi:10.1111/j.1749-6632.2002.tb02978.x. PMID 12021115.
- Sanjeevi CB, Das AK, Shtauvere-Brameus A (2002). "BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India". Ann. N. Y. Acad. Sci. 958: 293–6. doi:10.1111/j.1749-6632.2002.tb02990.x. PMID 12021127.
- Bearzatto M, Lampasona V, Belloni C, Bonifacio E (2004). "Fine mapping of diabetes-associated IA-2 specific autoantibodies". J. Autoimmun. 21 (4): 377–82. doi:10.1016/j.jaut.2003.08.002. PMID 14624760.
- Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch KP, Müller S et al. (2005). "Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells.". J. Cell Biol. 167 (6): 1063–74. doi:10.1083/jcb.200408172. PMC 2172607. PMID 15596545.
- Ota T, Takamura T, Nagai Y, Bando Y, Usuda R (2005). "Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody". Diabetes Res. Clin. Pract. 67 (1): 63–9. doi:10.1016/j.diabres.2004.05.004. PMID 15620435.
PDB gallery |
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| | 2i1y: Crystal structure of the phosphatase domain of human PTP IA-2 |
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