PTBP2
| Polypyrimidine tract binding protein 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PTBP2 ; PTB; PTBLP; brPTB; nPTB; nPTB5; nPTB6; nPTB7; nPTB8 | ||||||||||||
| External IDs | OMIM: 608449 MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 58155 | 56195 | |||||||||||
| Ensembl | ENSG00000117569 | ENSMUSG00000028134 | |||||||||||
| UniProt | Q9UKA9 | Q91Z31 | |||||||||||
| RefSeq (mRNA) | NM_021190 | NM_019550 | |||||||||||
| RefSeq (protein) | NP_067013 | NP_062423 | |||||||||||
| Location (UCSC) | Chr 1: 97.19 – 97.28 Mb | Chr 3: 119.72 – 119.78 Mb | |||||||||||
| PubMed search | |||||||||||||
Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.[1][2]
Function
The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.[2]
References
- ↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
- ↑ 2.0 2.1 "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".
This article incorporates text from the United States National Library of Medicine, which is in the public domain.