PSMC2

Proteasome (prosome, macropain) 26S subunit, ATPase, 2
Identifiers
SymbolsPSMC2 ; MSS1; Nbla10058; S7
External IDsOMIM: 154365 MGI: 109555 HomoloGene: 2096 GeneCards: PSMC2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez570119181
EnsemblENSG00000161057ENSMUSG00000028932
UniProtP35998P46471
RefSeq (mRNA)NM_001204453NM_011188
RefSeq (protein)NP_001191382NP_035318
Location (UCSC)Chr 7:
102.98 – 103.01 Mb		Chr 5:
21.79 – 21.8 Mb
PubMed search

26S protease regulatory subunit 7 is an enzyme that in humans is encoded by the PSMC2 gene.[1][2][3]

Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.[3]

Interactions

PSMC2 has been shown to interact with:

References

  1. ↑ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH et al. (March 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509.
  2. ↑ Shibuya H, Irie K, Ninomiya-Tsuji J, Goebl M, Taniguchi T, Matsumoto K (July 1992). "New human gene encoding a positive modulator of HIV Tat-mediated transactivation". Nature 357 (6380): 700–2. doi:10.1038/357700a0. PMID 1377363.
  3. ↑ 3.0 3.1 "Entrez Gene: PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2".
  4. ↑ Chen Y, Sharp ZD, Lee WH (September 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". J. Biol. Chem. 272 (38): 24081–7. doi:10.1074/jbc.272.38.24081. PMID 9295362.
  5. ↑ 5.0 5.1 Gorbea C, Taillandier D, Rechsteiner M (January 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J. Biol. Chem. 275 (2): 875–82. doi:10.1074/jbc.275.2.875. PMID 10625621.
  6. ↑ 6.0 6.1 Hartmann-Petersen R, Tanaka K, Hendil KB (February 2001). "Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking". Arch. Biochem. Biophys. 386 (1): 89–94. doi:10.1006/abbi.2000.2178. PMID 11361004.
  7. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading