PRSS2

Protease, serine, 2 (trypsin 2)
Identifiers
SymbolsPRSS2 ; TRY2; TRY8; TRYP2
External IDsOMIM: 601564 HomoloGene: 122141 IUPHAR: 2398 GeneCards: PRSS2 Gene
EC number3.4.21.4
Orthologs
SpeciesHumanMouse
Entrez564522072
EnsemblENSG00000204983ENSMUSG00000057163
UniProtP07478P07146
RefSeq (mRNA)NM_002770NM_009430
RefSeq (protein)NP_002761NP_033456
Location (UCSC)Chr 7:
142.46 – 142.46 Mb		Chr 6:
41.52 – 41.53 Mb
PubMed search

Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene. [1]

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].

References

  1. ↑ "Entrez Gene: Protease, serine, 2 (trypsin 2)". Retrieved 2013-08-20.

Further reading

  • Williams, S. J.; Gotley, D. C.; Antalis, T. M. (2001). "Human trypsinogen in colorectal cancer". International Journal of Cancer 93 (1): 67–73. doi:10.1002/ijc.1304. PMID 11391623.
  • Mayumi, T.; Inui, K.; Maetani, I.; Yokoe, M.; Sakamoto, T.; Yoshida, M.; Ko, S.; Hirata, K.; Takada, T.; Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP Study Group) (2012). "Validity of the Urinary Trypsinogen-2 Test in the Diagnosis of Acute Pancreatitis". Pancreas 41 (6): 869–875. doi:10.1097/MPA.0b013e3182480ab7. PMID 22481290.
  • Solomon, S.; Whitcomb, D. C.; Larusch, J.; Pagon, R. A.; Adam, M. P.; Bird, T. D.; Dolan, C. R.; Fong, C. T.; Stephens, K. (1993). "PRSS1-Related Hereditary Pancreatitis". PMID 22379635.
  • Ahmed, M.; Forsberg, J.; Bergsten, P. (2005). "Protein Profiling of Human Pancreatic Islets by Two-Dimensional Gel Electrophoresis and Mass Spectrometry". Journal of Proteome Research 4 (3): 931–940. doi:10.1021/pr050024a. PMID 15952740.
  • Vilen, S. T.; Suojanen, J.; Salas, F.; Risteli, J.; Ylipalosaari, M.; Itkonen, O.; Koistinen, H.; Baumann, M.; Stenman, U. H. K.; Sorsa, T.; Salo, T.; Nyberg, P. (2012). "Trypsin-2 Enhances Carcinoma Invasion by Processing Tight Junctions and Activating ProMT1-MMP". Cancer Investigation 30 (8): 583–592. doi:10.3109/07357907.2012.716467. PMID 22909050.
  • Lempinen, M.; Isoniemi, H.; Mäkisalo, H.; Nordin, A.; Halme, L.; Arola, J.; Höckerstedt, K.; Stenman, U. H. K. (2007). "Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures". Journal of Hepatology 47 (5): 677–683. doi:10.1016/j.jhep.2007.05.017. PMID 17640760.
  • Galey, D.; Becker, K.; Haughey, N.; Kalehua, A.; Taub, D.; Woodward, J.; Mattson, M. P.; Nath, A. (2003). "Differential Transcriptional Regulation by Human Immunodeficiency Virus Type 1 and gp120 in Human Astrocytes". Journal of Neurovirology 9 (3): 358–371. doi:10.1080/13550280390201119. PMID 12775419.
  • Baptista, A. M.; Jonson, P. H.; Hough, E.; Petersen, S. B. (1998). "The origin of trypsin: Evidence for multiple gene duplications in trypsins". Journal of molecular evolution 47 (3): 353–362. doi:10.1007/PL00006393. PMID 9732462.
  • Gao, J.; Zhu, F.; Lv, S.; Li, Z.; Ling, Z.; Gong, Y.; Jie, C.; Ma, L. (2010). "Identification of pancreatic juice proteins as biomarkers of pancreatic cancer". Oncology reports 23 (6): 1683–1692. doi:10.3892/or_00000812. PMID 20428826.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.