PRKACA

Protein kinase, cAMP-dependent, catalytic, alpha
PDB rendering based on 1apm.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6, 4AE9
Identifiers
Symbols	PRKACA ; PKACA
External IDs	OMIM: 601639 HomoloGene: 121574 IUPHAR: 1476 ChEMBL: 4101 GeneCards: PRKACA Gene
EC number	2.7.11.11
Gene ontology Molecular function • cAMP-dependent protein kinase activity • protein serine/threonine/tyrosine kinase activity • protein binding • ATP binding • protein kinase binding • ubiquitin protein ligase binding • protein kinase A regulatory subunit binding Cellular component • nucleus • mitochondrion • centrosome • cytosol • plasma membrane • cilium • cAMP-dependent protein kinase complex • membrane • AMP-activated protein kinase complex • neuromuscular junction • calcium channel complex • extracellular vesicular exosome • sperm midpiece Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • mesoderm formation • regulation of heart rate • carbohydrate metabolic process • glucose metabolic process • gluconeogenesis • energy reserve metabolic process • protein phosphorylation • water transport • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • blood coagulation • fibroblast growth factor receptor signaling pathway • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • peptidyl-serine phosphorylation • triglyceride catabolic process • activation of protein kinase A activity • intracellular signal transduction • calcium-mediated signaling using intracellular calcium source • regulation of protein binding • small molecule metabolic process • innate immune response • regulation of osteoblast differentiation • protein autophosphorylation • positive regulation of protein export from nucleus • neurotrophin TRK receptor signaling pathway • sperm capacitation • regulation of insulin secretion • regulation of synaptic transmission • cytosolic calcium ion homeostasis • transmembrane transport • regulation of cardiac muscle contraction • regulation of ryanodine-sensitive calcium-release channel activity • regulation of proteasomal protein catabolic process • positive regulation of cell cycle arrest • cellular response to glucose stimulus • cellular response to parathyroid hormone stimulus • cellular response to glucagon stimulus • cellular response to epinephrine stimulus • cell communication by electrical coupling involved in cardiac conduction • regulation of tight junction assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5566	18747
Ensembl	ENSG00000072062	ENSMUSG00000005469
UniProt	P17612	P05132
RefSeq (mRNA)	NM_002730	NM_001277898
RefSeq (protein)	NP_002721	NP_001264827
Location (UCSC)	Chr 19: 14.2 – 14.23 Mb	Chr 8: 83.97 – 84 Mb
PubMed search

cAMP-dependent protein kinase catalytic subunit alpha is an enzyme that in humans is encoded by the PRKACA gene.^[1]

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the Protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit|]]

Nicotine Activity on Dopaminergic Neurons edit

1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

Interactions

PRKACA has been shown to interact with Phosphoinositide-dependent kinase-1,^[3] IQGAP1,^[4] KvLQT1^[5] and Ryanodine receptor 2.^[6]

References

Further reading

PDB gallery 1apm: 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT  1atp: 2.2 angstrom refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MNATP and a peptide inhibitor  1bkx: A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY  1bx6: CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE  1cdk: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C  1cmk: CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS  1ctp: STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION  1fmo: CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE  1j3h: Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit  1jbp: Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Substrate Peptide, ADP and Detergent  1jlu: Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Phosphorylated Substrate Peptide and Detergent  1l3r: Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase  1q24: PKA double mutant model of PKB in complex with MgATP  1q61: PKA triple mutant model of PKB  1q62: PKA double mutant model of PKB  1q8t: The Catalytic Subunit of cAMP-dependent Protein Kinase (PKA) in Complex with Rho-kinase Inhibitor Y-27632  1q8u: The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P  1q8w: The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)  1rdq: Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase  1re8: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2  1rej: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1  1rek: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 8  1smh: Protein kinase A variant complex with completely ordered N-terminal helix  1stc: CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH STAUROSPORINE  1sve: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 1  1svg: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 4  1svh: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 8  1syk: Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation  1szm: DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)  1veb: Crystal Structure of Protein Kinase A in Complex with Azepane Derivative 5  1xh4: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh5: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh6: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh7: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh8: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xh9: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1xha: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants  1ydr: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE  1yds: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR [N-(2-METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE  1ydt: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITOR N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE  2c1a: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE  2c1b: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE  2cpk: CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CYCLIC ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE  2erz: Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil  2f7e: PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine  2f7x: Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine  2f7z: Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine  2gfc: cAMP-dependent protein kinase PKA catalytic subunit with PKI-5-24  2gnf: Protein kinase A fivefold mutant model of Rho-kinase with Y-27632  2gng: Protein kinase A fivefold mutant model of Rho-kinase  2gnh: PKA five fold mutant model of Rho-kinase with H1152P  2gni: PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077)  2gnj: PKA three fold mutant model of Rho-kinase with Y-27632  2gnl: PKA threefold mutant model of Rho-kinase with inhibitor H-1152P  2gu8: Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies  2jds: STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A-443654  2jdt: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL) AMIDE  2jdv: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH A-443654  2oh0: Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors  2ojf: Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors  2uvx: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 7-AZAINDOLE  2uvy: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH METHYL-(4-(9H-PURIN-6-YL)-BENZYL)-AMINE  2uvz: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH C-PHENYL-C-(4-(9H-PURIN-6-YL)-PHENYL)-METHYLAMINE  2uw0: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE  2uw3: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 5-METHYL-4-PHENYL-1H-PYRAZOLE  2uw4: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 2-(4-(5-METHYL-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE  2uw5: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (R)-2-(4-CHLORO-PHENYL)-2-(4-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE  2uw6: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (S)-2-(4-CHLORO-PHENYL)-2-(4-1H-PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE  2uw7: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 4-(4-CHLORO-PHENYL)-4-(4-(1H-PYRAZOL-4-YL)-PHENYL)-PIPERIDINE  2uw8: STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 2-(4-CHLORO-PHENYL)-2-PHENYL-ETHYLAMINE  2uzt: PKA STRUCTURES OF AKT, INDAZOLE-PYRIDINE INHIBITORS  2uzu: PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS  2uzv: PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS  2uzw: PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS