PPP4C
| Protein phosphatase 4, catalytic subunit | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PPP4C ; PP4; PP4C; PPH3; PPP4; PPX | ||||||||||||
| External IDs | OMIM: 602035 MGI: 1891763 HomoloGene: 2038 GeneCards: PPP4C Gene | ||||||||||||
| EC number | 3.1.3.16 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5531 | 56420 | |||||||||||
| Ensembl | ENSG00000149923 | ENSMUSG00000030697 | |||||||||||
| UniProt | P60510 | P97470 | |||||||||||
| RefSeq (mRNA) | NM_002720 | NM_019674 | |||||||||||
| RefSeq (protein) | NP_002711 | NP_062648 | |||||||||||
| Location (UCSC) | Chr 16: 30.08 – 30.09 Mb | Chr 7: 126.79 – 126.79 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.[1][2]
Interactions
PPP4C has been shown to interact with CCT2,[3][4] CCT4,[3][4] CCT7,[3][4] SMEK2,[3][4][5] CCT6A,[3][4] CCT3,[3][4] IGBP1,[3][4][6] PPP4R1,[3][4][5] CCT5,[3][4] T-complex 1,[3][4] REL,[7] CCDC6,[3][5] TRAF6[8] and PPP2R1A.[3][5]
References
- ↑ Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (Jul 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.
- ↑ "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 3.10 3.11 Chen, Ginny I; Tisayakorn Sally, Jorgensen Claus, D'Ambrosio Lisa M, Goudreault Marilyn, Gingras Anne-Claude (October 2008). "PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4". J. Biol. Chem. (United States) 283 (43): 29273–84. doi:10.1074/jbc.M803443200. ISSN 0021-9258. PMC 2662017. PMID 18715871.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Gingras, Anne-Claude; Caballero Michael; Zarske Marcel; Sanchez Amy; Hazbun Tony R; Fields Stanley; Sonenberg Nahum; Hafen Ernst; Raught Brian; Aebersold Ruedi (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell Proteomics (United States) 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. ISSN 1535-9476. PMID 16085932.
- ↑ 5.0 5.1 5.2 5.3 Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- ↑ Chen, J; Peterson R T; Schreiber S L (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochem. Biophys. Res. Commun. (United States) 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. ISSN 0006-291X. PMID 9647778.
- ↑ Hu, M C; Tang-Oxley Q; Qiu W R; Wang Y P; Mihindukulasuriya K A; Afshar R; Tan T H (December 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". J. Biol. Chem. (United States) 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. ISSN 0021-9258. PMID 9837938.
- ↑ Chen, Lu; Dong Wei; Zou Tingting; Ouyang Lu; He Guoqing; Liu Yingle; Qi Yipeng (August 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Lett. (Netherlands) 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. ISSN 0014-5793. PMID 18634786.
Further reading
- Brewis ND, Cohen PT (1993). "Protein phosphatase X has been highly conserved during mammalian evolution". Biochim. Biophys. Acta 1171 (2): 231–3. doi:10.1016/0167-4781(92)90129-n. PMID 1336397.
- Brewis ND, Street AJ, Prescott AR, Cohen PT (1993). "PPX, a novel protein serine/threonine phosphatase localized to centrosomes". EMBO J. 12 (3): 987–96. PMC 413299. PMID 8384557.
- Kloeker S; Bryant JC; Strack S et al. (1997). "Carboxymethylation of nuclear protein serine/threonine phosphatase X". Biochem. J. 327 (Pt 2): 481–6. PMC 1218819. PMID 9359419.
- Chen J, Peterson RT, Schreiber SL (1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochem. Biophys. Res. Commun. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
- Hu MC; Tang-Oxley Q; Qiu WR et al. (1999). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". J. Biol. Chem. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
- Kloeker S, Wadzinski BE (1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". J. Biol. Chem. 274 (9): 5339–47. doi:10.1074/jbc.274.9.5339. PMID 10026142.
- Hastie CJ, Carnegie GK, Morrice N, Cohen PT (2000). "A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres". Biochem. J. 347 (Pt 3): 845–55. doi:10.1042/0264-6021:3470845. PMC 1221024. PMID 10769191.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Carnegie GK; Sleeman JE; Morrice N et al. (2004). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. PMID 12668731.
- Yeh PY; Yeh KH; Chuang SE et al. (2004). "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation". J. Biol. Chem. 279 (25): 26143–8. doi:10.1074/jbc.M402362200. PMID 15073167.
- Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation". J. Biol. Chem. 279 (45): 46588–94. doi:10.1074/jbc.M408067200. PMID 15331607.
- Zhou G, Boomer JS, Tan TH (2005). "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1". J. Biol. Chem. 279 (47): 49551–61. doi:10.1074/jbc.M410317200. PMID 15364934.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Zhang X; Ozawa Y; Lee H et al. (2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes Dev. 19 (7): 827–39. doi:10.1101/gad.1286005. PMC 1074320. PMID 15805470.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ewing RM; Chu P; Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.