PPP3CC
| Protein phosphatase 3, catalytic subunit, gamma isozyme | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PPP3CC ; CALNA3; CNA3; PP2Bgamma | ||||||||||||
| External IDs | OMIM: 114107 MGI: 107162 HomoloGene: 68475 ChEMBL: 2694 GeneCards: PPP3CC Gene | ||||||||||||
| EC number | 3.1.3.16 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5533 | 19057 | |||||||||||
| Ensembl | ENSG00000120910 | ENSMUSG00000022092 | |||||||||||
| UniProt | P48454 | P48455 | |||||||||||
| RefSeq (mRNA) | NM_001243974 | NM_008915 | |||||||||||
| RefSeq (protein) | NP_001230903 | NP_032941 | |||||||||||
| Location (UCSC) | Chr 8: 22.3 – 22.4 Mb | Chr 14: 70.22 – 70.29 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PPP3CC gene.[1][2]
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM][2]
References
- ↑ Muramatsu T, Kincaid RL (Nov 1992). "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)". Biochem Biophys Res Commun 188 (1): 265–71. doi:10.1016/0006-291X(92)92379-C. PMID 1339277.
- ↑ 2.0 2.1 "Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform".
Further reading
- Esau C; Boes M; Youn HD et al. (2001). "Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells". J. Exp. Med. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
- Gerber DJ; Hall D; Miyakawa T et al. (2003). "Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8993–8. doi:10.1073/pnas.1432927100. PMC 166426. PMID 12851458.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Barrios-Rodiles M; Brown KR; Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Eastwood SL, Burnet PW, Harrison PJ (2005). "Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia". Biol. Psychiatry 57 (7): 702–10. doi:10.1016/j.biopsych.2004.12.029. PMID 15820226.
- Kinoshita Y; Suzuki T; Ikeda M et al. (2006). "No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia". Journal of neural transmission (Vienna, Austria : 1996) 112 (9): 1255–62. doi:10.1007/s00702-004-0261-5. PMID 15843870.
- Liu YL; Fann CS; Liu CM et al. (2008). "More evidence supports the association of PPP3CC with schizophrenia". Mol. Psychiatry 12 (10): 966–74. doi:10.1038/sj.mp.4001977. PMID 17339875.
- Horiuchi Y; Ishiguro H; Koga M et al. (2008). "Support for association of the PPP3CC gene with schizophrenia". Mol. Psychiatry 12 (10): 891–3. doi:10.1038/sj.mp.4002019. PMID 17895921.