PPP2R5C
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.[1][2]
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]
Interactions
PPP2R5C has been shown to interact with PPP2R1B[3] and PPP2CA.[3][4][5]
References
- ↑ McCright B, Virshup DM (December 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
- ↑ 2.0 2.1 "Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform".
- ↑ 3.0 3.1 McCright, B; Rivers A M; Audlin S; Virshup D M (September 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. (UNITED STATES) 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017.
- ↑ Ito, A; Kataoka T R; Watanabe M; Nishiyama K; Mazaki Y; Sabe H; Kitamura Y; Nojima H (February 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". EMBO J. (ENGLAND) 19 (4): 562–71. doi:10.1093/emboj/19.4.562. ISSN 0261-4189. PMC 305594. PMID 10675325.
- ↑ Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). "A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
Further reading
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Nomura N, Miyajima N, Sazuka T et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
- Nomura N, Nagase T, Miyajima N et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
- Akiyama N, Shima H, Hatano Y et al. (1995). "cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase". Eur. J. Biochem. 230 (2): 766–72. doi:10.1111/j.1432-1033.1995.tb20619.x. PMID 7607250.
- Tehrani MA, Mumby MC, Kamibayashi C (1996). "Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle". J. Biol. Chem. 271 (9): 5164–70. doi:10.1074/jbc.271.9.5164. PMID 8617797.
- Zolnierowicz S, Van Hoof C, Andjelković N et al. (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". Biochem. J. 317 ( Pt 1) (Pt 1): 187–94. PMC 1217462. PMID 8694763.
- McCright B, Rivers AM, Audlin S, Virshup DM (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
- McCright B, Brothman AR, Virshup DM (1997). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429.
- Tung HY, De Rocquigny H, Zhao LJ et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
- Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
- Scanlan MJ, Gordan JD, Williamson B et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Ito A, Kataoka TR, Watanabe M et al. (2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". EMBO J. 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC 305594. PMID 10675325.
- Ikeda S, Kishida M, Matsuura Y et al. (2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". Oncogene 19 (4): 537–45. doi:10.1038/sj.onc.1203359. PMID 10698523.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G2 cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMC 306605. PMID 10921877. (Retracted. If this is intentional, please replace
{{Retracted}}with{{Retracted|intentional=yes}}.) - Elder RT, Yu M, Chen M et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
- Muneer S, Ramalingam V, Wyatt R et al. (2002). "Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit". Genomics 79 (3): 344–8. doi:10.1006/geno.2002.6721. PMID 11863364.
- Strack S, Ruediger R, Walter G et al. (2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". J. Biol. Chem. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.
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