PPP2R5B
| Protein phosphatase 2, regulatory subunit B', beta | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PPP2R5B ; B56B; PR61B | ||||||||||||
| External IDs | OMIM: 601644 MGI: 2388480 HomoloGene: 38157 GeneCards: PPP2R5B Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5526 | 225849 | |||||||||||
| Ensembl | ENSG00000068971 | ENSMUSG00000024777 | |||||||||||
| UniProt | Q15173 | Q6PD28 | |||||||||||
| RefSeq (mRNA) | NM_006244 | NM_198168 | |||||||||||
| RefSeq (protein) | NP_006235 | NP_937811 | |||||||||||
| Location (UCSC) | Chr 11: 64.69 – 64.7 Mb | Chr 19: 6.23 – 6.24 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.[1][2]
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily.[2]
Interactions
PPP2R5B has been shown to interact with PPP2R1B[3] and PPP2CA.[3][4]
References
- ↑ McCright B, Virshup DM (Dec 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
- ↑ 2.0 2.1 "Entrez Gene: PPP2R5B protein phosphatase 2, regulatory subunit B', beta isoform".
- ↑ 3.0 3.1 McCright, B; Rivers A M; Audlin S; Virshup D M (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. (UNITED STATES) 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017.
- ↑ Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
Further reading
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle.". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column.". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
- Zolnierowicz S, Van Hoof C, Andjelković N et al. (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.". Biochem. J. 317 (1): 187–94. PMC 1217462. PMID 8694763.
- McCright B, Rivers AM, Audlin S, Virshup DM (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.". J. Biol. Chem. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
- McCright B, Brothman AR, Virshup DM (1997). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.". Genomics 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429.
- Tung HY, De Rocquigny H, Zhao LJ et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.". FEBS Lett. 401 (2-3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
- Forbes SA, Pannett AA, Bassett JH et al. (1997). "Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1).". Hum. Genet. 100 (3-4): 481–5. doi:10.1007/s004390050538. PMID 9272177.
- Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
- Ikeda S, Kishida M, Matsuura Y et al. (2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.". Oncogene 19 (4): 537–45. doi:10.1038/sj.onc.1203359. PMID 10698523.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMC 306605. PMID 10921877. (Retracted. If this is intentional, please replace
{{Retracted}}with{{Retracted|intentional=yes}}.) - Elder RT, Yu M, Chen M et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.". EMBO J. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC 126131. PMID 12110603.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Galey D, Becker K, Haughey N et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes.". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dozier C, Bonyadi M, Baricault L et al. (2005). "Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.". Biol. Cell 96 (7): 509–17. doi:10.1016/j.biolcel.2004.04.010. PMID 15380617.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.