PPP2R5A
| Protein phosphatase 2, regulatory subunit B', alpha | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PPP2R5A ; B56A; PR61A | ||||||||||||
| External IDs | OMIM: 601643 MGI: 2388479 HomoloGene: 55961 ChEMBL: 4763 GeneCards: PPP2R5A Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5525 | 226849 | |||||||||||
| Ensembl | ENSG00000066027 | ENSMUSG00000026626 | |||||||||||
| UniProt | Q15172 | Q6PD03 | |||||||||||
| RefSeq (mRNA) | NM_001199756 | NM_144880 | |||||||||||
| RefSeq (protein) | NP_001186685 | NP_659129 | |||||||||||
| Location (UCSC) | Chr 1: 212.46 – 212.54 Mb | Chr 1: 191.35 – 191.4 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.[1]
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.[2]
Interactions
PPP2R5A has been shown to interact with PPP2R1B,[3][4][5] PPP2R1A,[3][4] CTLA-4,[6] AXIN1[7] and PPP2CA.[3][5]
References
- ↑ McCright B, Virshup DM (December 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
- ↑ "Entrez Gene: PPP2R5A protein phosphatase 2, regulatory subunit B', alpha isoform".
- ↑ 3.0 3.1 3.2 Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
- ↑ 4.0 4.1 Zhou, Jin; Pham Huong T; Ruediger Ralf; Walter Gernot (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. (England) 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081.
- ↑ 5.0 5.1 McCright, B; Rivers A M; Audlin S; Virshup D M (September 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. (UNITED STATES) 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017.
- ↑ Baroja, Miren L; Vijayakrishnan Lalitha; Bettelli Estelle; Darlington Peter J; Chau Thu A; Ling Vincent; Collins Mary; Carreno Beatriz M; Madrenas Joaquín; Kuchroo Vijay K (May 2002). "Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A". J. Immunol. (United States) 168 (10): 5070–8. doi:10.4049/jimmunol.168.10.5070. ISSN 0022-1767. PMID 11994459.
- ↑ Yamamoto, H; Hinoi T; Michiue T; Fukui A; Usui H; Janssens V; Van Hoof C; Goris J; Asashima M; Kikuchi A (July 2001). "Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A". J. Biol. Chem. (United States) 276 (29): 26875–82. doi:10.1074/jbc.M100443200. ISSN 0021-9258. PMID 11297546.
Further reading
- Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis.". Curr. HIV Res. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle.". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Zolnierowicz S, Van Hoof C, Andjelković N et al. (1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.". Biochem. J. 317 (1): 187–94. PMC 1217462. PMID 8694763.
- Fuhrer DK, Yang YC (1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11.". Biochem. Biophys. Res. Commun. 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. PMID 8702385.
- McCright B, Rivers AM, Audlin S, Virshup DM (1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.". J. Biol. Chem. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
- McCright B, Brothman AR, Virshup DM (1997). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.". Genomics 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Tung HY, De Rocquigny H, Zhao LJ et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.". FEBS Lett. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
- Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
- Ruediger R, Fields K, Walter G (1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". J. Virol. 73 (1): 839–42. PMC 103900. PMID 9847399.
- Seeling JM, Miller JR, Gil R et al. (1999). "Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A". Science 283 (5410): 2089–91. doi:10.1126/science.283.5410.2089. PMID 10092233.
- Xu Z, Williams BR (2000). "The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR". Mol. Cell. Biol. 20 (14): 5285–99. doi:10.1128/MCB.20.14.5285-5299.2000. PMC 85978. PMID 10866685.
- Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMC 306605. PMID 10921877. (Retracted. If this is intentional, please replace
{{Retracted}}with{{Retracted|intentional=yes}}.) - Fleming I, Fisslthaler B, Dimmeler S et al. (2001). "Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity". Circ. Res. 88 (11): E68–75. doi:10.1161/hh1101.092677. PMID 11397791.
- Elder RT, Yu M, Chen M et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
- Galea MA, Eleftheriou A, Henderson BR (2002). "ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A". J. Biol. Chem. 276 (49): 45833–9. doi:10.1074/jbc.M107149200. PMID 11585828.
- Li X, Virshup DM (2002). "Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A". Eur. J. Biochem. 269 (2): 546–52. doi:10.1046/j.0014-2956.2001.02680.x. PMID 11856313.