PPP2R3B
| Protein phosphatase 2, regulatory subunit B, beta | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | PPP2R3B ; NYREN8; PPP2R3L; PPP2R3LY; PR48 | ||||||||||||
| External IDs | OMIM: 300339 HomoloGene: 61474 GeneCards: PPP2R3B Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 28227 | n/a | |||||||||||
| Ensembl | ENSG00000167393 | n/a | |||||||||||
| UniProt | Q9Y5P8 | n/a | |||||||||||
| RefSeq (mRNA) | NM_013239 | n/a | |||||||||||
| RefSeq (protein) | NP_037371 | n/a | |||||||||||
| Location (UCSC) | Chr X: 0.29 – 0.35 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.[1][2]
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]
Interactions
PPP2R3B has been shown to interact with PPP2R1B,[3] PPP2R1A,[3][4] CDC6[5] and PPP2CA.[4][5]
References
- ↑ Schiebel K, Meder J, Rump A, Rosenthal A, Winkelmann M, Fischer C, Bonk T, Humeny A, Rappold G (February 2001). "Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region". Cytogenet Cell Genet 91 (1–4): 224–30. doi:10.1159/000056849. PMID 11173861.
- ↑ 2.0 2.1 "Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta".
- ↑ 3.0 3.1 Zhou, Jin; Pham Huong T; Ruediger Ralf; Walter Gernot (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. (England) 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081.
- ↑ 4.0 4.1 Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). "A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
- ↑ 5.0 5.1 Yan, Z; Fedorov S A; Mumby M C; Williams R S (February 2000). "PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. ISSN 0270-7306. PMC 85219. PMID 10629059.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Ruediger R, Fields K, Walter G (1999). "Binding Specificity of Protein Phosphatase 2A Core Enzyme for Regulatory B Subunits and T Antigens". J. Virol. 73 (1): 839–42. PMC 103900. PMID 9847399.
- Scanlan MJ, Gordan JD, Williamson B et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Yan Z, Fedorov SA, Mumby MC, Williams RS (2000). "PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells". Mol. Cell. Biol. 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.
- Yokoyama N, Miller WT (2001). "Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS)". Oncogene 20 (42): 6057–65. doi:10.1038/sj.onc.1204735. PMID 11593413.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Stevens I, Janssens V, Martens E et al. (2003). "Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues". Eur. J. Biochem. 270 (2): 376–87. doi:10.1046/j.1432-1033.2003.03398.x. PMID 12605688.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gao Y, Kitagawa K, Hiramatsu Y et al. (2007). "Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis". Cancer Res. 66 (24): 11623–31. doi:10.1158/0008-5472.CAN-06-2629. PMID 17178856.