PPP2R1B

Protein phosphatase 2, regulatory subunit A, beta
Identifiers
SymbolsPPP2R1B ; PP2A-Abeta; PR65B
External IDsOMIM: 603113 MGI: 1920949 HomoloGene: 70244 GeneCards: PPP2R1B Gene
EC number3.1.3.16
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez551973699
EnsemblENSG00000137713ENSMUSG00000032058
UniProtP30154Q7TNP2
RefSeq (mRNA)NM_001177562NM_001034085
RefSeq (protein)NP_001171033NP_001029257
Location (UCSC)Chr 11:
111.6 – 111.64 Mb		Chr 9:
50.85 – 50.89 Mb
PubMed search

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.[1][2][3]

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

PPP2R1B has been shown to interact with PPP2R5E,[4] PPP2R5D,[4] PPP2R3B,[5] PPP2R2A,[5][6] PPP2R5C,[4] PPP2R5B,[4] PPP2R5A,[4][5][7] PPP2CB[5] and PPP2CA.[5][7]

References

  1. ↑ Hemmings BA, Adams-Pearson C, Maurer F, Muller P, Goris J, Merlevede W, Hofsteenge J, Stone SR (Jun 1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry 29 (13): 3166–73. doi:10.1021/bi00465a002. PMID 2159327.
  2. ↑ Baysal BE, Farr JE, Goss JR, Devlin B, Richard CW 3rd (Nov 1998). "Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23". Gene 217 (1–2): 107–16. doi:10.1016/S0378-1119(98)00350-3. PMID 9795170.
  3. ↑ 3.0 3.1 "Entrez Gene: PPP2R1B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform".
  4. ↑ 4.0 4.1 4.2 4.3 4.4 McCright, B; Rivers A M; Audlin S; Virshup D M (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. (United States) 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Zhou, Jin; Pham Huong T; Ruediger Ralf; Walter Gernot (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. (England) 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081.
  6. ↑ Kamibayashi, C; Lickteig R L; Estes R; Walter G; Mumby M C (Oct 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". J. Biol. Chem. (United States) 267 (30): 21864–72. ISSN 0021-9258. PMID 1328247.
  7. ↑ 7.0 7.1 Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (Jan 2009). "A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading

  • Zolnierowicz S (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochem. Pharmacol. 60 (8): 1225–35. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
  • Kamibayashi C; Lickteig RL; Estes R et al. (1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". J. Biol. Chem. 267 (30): 21864–72. PMID 1328247.
  • Tung HY; De Rocquigny H; Zhao LJ et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
  • Adler HT, Nallaseth FS, Walter G, Tkachuk DC (1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". J. Biol. Chem. 272 (45): 28407–14. doi:10.1074/jbc.272.45.28407. PMID 9353299.
  • Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
  • Wang SS; Esplin ED; Li JL et al. (1998). "Alterations of the PPP2R1B gene in human lung and colon cancer". Science 282 (5387): 284–7. doi:10.1126/science.282.5387.284. PMID 9765152.
  • Takahashi M; Shibata H; Shimakawa M et al. (1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus". J. Biol. Chem. 274 (24): 17267–74. doi:10.1074/jbc.274.24.17267. PMID 10358086.
  • Campbell IG, Manolitsas T (2000). "Absence of PPP2R1B gene alterations in primary ovarian cancers". Oncogene 18 (46): 6367–9. doi:10.1038/sj.onc.1203070. PMID 10597236.
  • Takagi Y; Futamura M; Yamaguchi K et al. (2000). "Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers". Gut 47 (2): 268–71. doi:10.1136/gut.47.2.268. PMC 1727986. PMID 10896920.
  • Baysal BE; Willett-Brozick JE; Taschner PE et al. (2001). "A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region". Eur. J. Hum. Genet. 9 (2): 121–9. doi:10.1038/sj.ejhg.5200585. PMID 11313745.
  • Ruediger R, Pham HT, Walter G (2001). "Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene". Oncogene 20 (15): 1892–9. doi:10.1038/sj.onc.1204279. PMID 11313937.
  • Yokoyama N, Reich NC, Miller WT (2001). "Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway". J. Interferon Cytokine Res. 21 (6): 369–78. doi:10.1089/107999001750277844. PMID 11440634.
  • Elder RT; Yu M; Chen M et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
  • Yang J; Fan GH; Wadzinski BE et al. (2002). "Protein Phosphatase 2A Interacts with and Directly Dephosphorylates RelA". J. Biol. Chem. 276 (51): 47828–33. doi:10.1074/jbc.M106103200. PMC 2665282. PMID 11591705.
  • Strack S; Ruediger R; Walter G et al. (2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". J. Biol. Chem. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.
  • Hemmer S; Wasenius VM; Haglund C et al. (2002). "Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas". Cancer Genet. Cytogenet. 134 (1): 13–7. doi:10.1016/S0165-4608(01)00597-0. PMID 11996789.