PPP2CA

Protein phosphatase 2, catalytic subunit, alpha isozyme

PDB rendering based on 2iae.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsPPP2CA ; PP2Ac; PP2CA; PP2Calpha; RP-C
External IDsOMIM: 176915 MGI: 1321159 HomoloGene: 37660 ChEMBL: 4703 GeneCards: PPP2CA Gene
EC number3.1.3.16
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez551519052
EnsemblENSG00000113575ENSMUSG00000020349
UniProtP67775P63330
RefSeq (mRNA)NM_002715NM_019411
RefSeq (protein)NP_002706NP_062284
Location (UCSC)Chr 5:
133.53 – 133.56 Mb		Chr 11:
52.1 – 52.13 Mb
PubMed search

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that (in humans) is encoded by the PPP2CA gene.[1]

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.[2]

Interactions

PPP2CA has been shown to interact with CCNG2,[3] CTTNBP2,[4] MOBKL3,[4] Bestrophin 1,[5] TLX1,[6] Bcl-2,[7] PPP2R3B,[4][8] Cyclin-dependent kinase 2,[9] STRN3,[4] Cyclin-dependent kinase 6,[9] IGBP1,[4][10][11][12] PPP2R5E,[4][13] STRN,[4] PPP2R5D,[4][13] PPP2R2A,[4][14] PPP2R1B,[4][15] PPP2R1A,[4][15] CTTNBP2NL,[4] FAM40A,[4] PPP2R5C,[4][13][16] PPP2R5B[4][13] and PPP2R5A.[4][13]

See also

PPP2CB

References

  1. ↑ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively". Cytogenet Cell Genet 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590.
  2. ↑ "Entrez Gene: PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform".
  3. ↑ Bennin, David A; Don Aruni S Arachchige, Brake Tiffany, McKenzie Jennifer L, Rosenbaum Heidi, Ortiz Linette, DePaoli-Roach Anna A, Horne Mary C (July 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. (United States) 277 (30): 27449–67. doi:10.1074/jbc.M111693200. ISSN 0021-9258. PMID 11956189.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 4.10 4.11 4.12 4.13 4.14 4.15 Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  5. ↑ Marmorstein, Lihua Y; McLaughlin Precious J; Stanton J Brett; Yan Lin; Crabb John W; Marmorstein Alan D (August 2002). "Bestrophin interacts physically and functionally with protein phosphatase 2A". J. Biol. Chem. (United States) 277 (34): 30591–7. doi:10.1074/jbc.M204269200. ISSN 0021-9258. PMID 12058047.
  6. ↑ Kawabe, T; Muslin A J; Korsmeyer S J (January 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature (ENGLAND) 385 (6615): 454–8. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195.
  7. ↑ Deng, X; Ito T; Carr B; Mumby M; May W S (December 1998). "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A". J. Biol. Chem. (UNITED STATES) 273 (51): 34157–63. doi:10.1074/jbc.273.51.34157. ISSN 0021-9258. PMID 9852076.
  8. ↑ Yan, Z; Fedorov S A; Mumby M C; Williams R S (February 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. ISSN 0270-7306. PMC 85219. PMID 10629059.
  9. ↑ 9.0 9.1 Cheng, A; Kaldis P; Solomon M J (November 2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms". J. Biol. Chem. (UNITED STATES) 275 (44): 34744–9. doi:10.1074/jbc.M006210200. ISSN 0021-9258. PMID 10934208.
  10. ↑ Gingras, Anne-Claude; Caballero Michael; Zarske Marcel; Sanchez Amy; Hazbun Tony R; Fields Stanley; Sonenberg Nahum; Hafen Ernst; Raught Brian; Aebersold Ruedi (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell Proteomics (United States) 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. ISSN 1535-9476. PMID 16085932.
  11. ↑ Chen, J; Peterson R T; Schreiber S L (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochem. Biophys. Res. Commun. (UNITED STATES) 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. ISSN 0006-291X. PMID 9647778.
  12. ↑ Chung, H; Nairn A C; Murata K; Brautigan D L (August 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry (UNITED STATES) 38 (32): 10371–6. doi:10.1021/bi990902g. ISSN 0006-2960. PMID 10441131.
  13. ↑ 13.0 13.1 13.2 13.3 13.4 McCright, B; Rivers A M; Audlin S; Virshup D M (September 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. (UNITED STATES) 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017.
  14. ↑ Kamibayashi, C; Lickteig R L; Estes R; Walter G; Mumby M C (October 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". J. Biol. Chem. (UNITED STATES) 267 (30): 21864–72. ISSN 0021-9258. PMID 1328247.
  15. ↑ 15.0 15.1 Zhou, Jin; Pham Huong T; Ruediger Ralf; Walter Gernot (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. (England) 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081.
  16. ↑ Ito, A; Kataoka T R; Watanabe M; Nishiyama K; Mazaki Y; Sabe H; Kitamura Y; Nojima H (February 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". EMBO J. (ENGLAND) 19 (4): 562–71. doi:10.1093/emboj/19.4.562. ISSN 0261-4189. PMC 305594. PMID 10675325.

Further reading