PPP1CB

Protein phosphatase 1, catalytic subunit, beta isozyme

PDB rendering based on 1s70.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsPPP1CB ; HEL-S-80p; PP-1B; PP1B; PP1beta; PPP1CD
External IDsOMIM: 600590 MGI: 104871 HomoloGene: 37659 ChEMBL: 4546 GeneCards: PPP1CB Gene
EC number3.1.3.16, 3.1.3.53
Orthologs
SpeciesHumanMouse
Entrez550019046
EnsemblENSG00000213639ENSMUSG00000014956
UniProtP62140P62141
RefSeq (mRNA)NM_002709NM_172707
RefSeq (protein)NP_002700NP_766295
Location (UCSC)Chr 2:
28.97 – 29.03 Mb
Chr 5:
32.46 – 32.52 Mb
PubMed search

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.[1]

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.[2]

Interactions

PPP1CB has been shown to interact with PPP1R15A,[3][4] Nucleolin,[5] SMARCB1[3] and PPP1R9B.[6]

References

  1. Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PT (March 1994). "Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB)". Biochim Biophys Acta 1220 (2): 212–8. doi:10.1016/0167-4889(94)90138-4. PMID 8312365.
  2. "Entrez Gene: PPP1CB protein phosphatase 1, catalytic subunit, beta isoform".
  3. 3.0 3.1 Wu, Daniel Y; Tkachuck Douglas C; Roberson Rachel S; Schubach William H (August 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. (United States) 277 (31): 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.
  4. Connor, J H; Weiser D C; Li S; Hallenbeck J M; Shenolikar S (October 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. (United States) 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.
  5. Morimoto, Hiroyuki; Okamura Hirohiko; Haneji Tatsuji (September 2002). "Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells". J. Histochem. Cytochem. (United States) 50 (9): 1187–93. doi:10.1177/002215540205000905. ISSN 0022-1554. PMID 12185196.
  6. Hsieh-Wilson, L C; Allen P B; Watanabe T; Nairn A C; Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry (UNITED STATES) 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.

Further reading