PPEF1
| Protein phosphatase, EF-hand calcium binding domain 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PPEF1 ; PP7; PPEF; PPP7C; PPP7CA | ||||||||||||
| External IDs | OMIM: 300109 MGI: 1097157 HomoloGene: 55960 GeneCards: PPEF1 Gene | ||||||||||||
| EC number | 3.1.3.16 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5475 | 237178 | |||||||||||
| Ensembl | ENSG00000086717 | ENSMUSG00000062168 | |||||||||||
| UniProt | O14829 | O35655 | |||||||||||
| RefSeq (mRNA) | NM_006240 | NM_011147 | |||||||||||
| RefSeq (protein) | NP_006231 | NP_035277 | |||||||||||
| Location (UCSC) | Chr X: 18.69 – 18.85 Mb | Chr X: 160.62 – 160.74 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase with EF-hands 1 is an enzyme that in humans is encoded by the PPEF1 gene.[1][2][3]
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.[3]
Interactions
PPEF1 has been shown to interact with Calmodulin 1.[4]
References
- ↑ Montini E, Rugarli EI, Van de Vosse E, Andolfi G, Mariani M, Puca AA, Consalez GG, den Dunnen JT, Ballabio A, Franco B (Aug 1997). "A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin". Hum Mol Genet 6 (7): 1137–45. doi:10.1093/hmg/6.7.1137. PMID 9215685.
- ↑ Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J (Nov 1997). "Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C (rdgC)". Proc Natl Acad Sci U S A 94 (21): 11639–44. doi:10.1073/pnas.94.21.11639. PMC 23563. PMID 9326663.
- ↑ 3.0 3.1 "Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1".
- ↑ Kutuzov, Mikhail A; Solov'eva Olga V, Andreeva Alexandra V, Bennett Nelly (May 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochem. Biophys. Res. Commun. (United States) 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. ISSN 0006-291X. PMID 12051765.
Further reading
- Herzig S, Neumann J (2000). "Effects of serine/threonine protein phosphatases on ion channels in excitable membranes". Physiol. Rev. 80 (1): 173–210. PMID 10617768.
- Huang X, Honkanen RE (1998). "Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)". J. Biol. Chem. 273 (3): 1462–8. doi:10.1074/jbc.273.3.1462. PMID 9430683.
- Ramulu P; Kennedy M; Xiong WH et al. (2001). "Normal Light Response, Photoreceptor Integrity, and Rhodopsin Dephosphorylation in Mice Lacking Both Protein Phosphatases with EF Hands (PPEF-1 and PPEF-2)". Mol. Cell. Biol. 21 (24): 8605–14. doi:10.1128/MCB.21.24.8605-8614.2001. PMC 100021. PMID 11713293.
- Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N (2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochem. Biophys. Res. Commun. 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. PMID 12051765.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K; Goethals M; Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT; Grafham DV; Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.