PON2

Paraoxonase 2
Identifiers
SymbolPON2
External IDsOMIM: 602447 MGI: 106687 HomoloGene: 385 GeneCards: PON2 Gene
EC number3.1.1.2, 3.1.1.81
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez5445330260
EnsemblENSG00000105854ENSMUSG00000032667
UniProtQ15165Q62086
RefSeq (mRNA)NM_000305NM_183308
RefSeq (protein)NP_000296NP_899131
Location (UCSC)Chr 7:
95.03 – 95.06 Mb
Chr 6:
5.26 – 5.3 Mb
PubMed search

Serum paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2 gene.[1][2][3]

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.[3]

References

  1. Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (Sep 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.
  2. Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui LC, Prochazka M (Aug 1998). "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence". Gene 213 (1–2): 149–57. doi:10.1016/S0378-1119(98)00193-0. PMID 9714608.
  3. 3.0 3.1 "Entrez Gene: PON2 paraoxonase 2".

Further reading