POLG2
DNA polymerase subunit gamma-2, mitochondrial is an protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene. [1][2][3]
References
- ↑ Wang Y, Farr CL, Kaguni LS (Jul 1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J Biol Chem 272 (21): 13640–6. doi:10.1074/jbc.272.21.13640. PMID 9153213.
- ↑ "Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit".
- ↑ Lim, SE; Longley, MJ; Copeland, WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893.
Further reading
- Michiels S, Danoy P, Dessen P et al. (2007). "Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.". Carcinogenesis 28 (8): 1731–9. doi:10.1093/carcin/bgm111. PMID 17494052.
- Huang H, Shiffman ML, Cheung RC et al. (2006). "Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C.". Gastroenterology 130 (6): 1679–87. doi:10.1053/j.gastro.2006.02.032. PMID 16697732.
- Longley MJ, Clark S, Yu Wai Man C et al. (2006). "Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia". Am. J. Hum. Genet. 78 (6): 1026–34. doi:10.1086/504303. PMC 1474082. PMID 16685652.
- Yakubovskaya E, Chen Z, Carrodeguas JA et al. (2006). "Functional human mitochondrial DNA polymerase gamma forms a heterotrimer". J. Biol. Chem. 281 (1): 374–82. doi:10.1074/jbc.M509730200. PMID 16263719.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Carrodeguas JA, Pinz KG, Bogenhagen DF (2003). "DNA binding properties of human pol gammaB". J. Biol. Chem. 277 (51): 50008–14. doi:10.1074/jbc.M207030200. PMID 12379656.
- Johnson AA, Tsai Y, Graves SW, Johnson KA (2000). "Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization". Biochemistry 39 (7): 1702–8. doi:10.1021/bi992104w. PMID 10677218.
- Carrodeguas JA, Bogenhagen DF (2000). "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase". Nucleic Acids Res. 28 (5): 1237–44. doi:10.1093/nar/28.5.1237. PMC 102604. PMID 10666468.
- Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893.
PDB gallery |
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| | 2g4c: Crystal Structure of human DNA polymerase gamma accessory subunit |
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