PNKP
Bifunctional polynucleotide phosphatase/kinase is an enzyme that in humans is encoded by the PNKP gene.[1][2][3]
Interactions
PNKP has been shown to interact with DNA polymerase beta[4] and XRCC1.[4][5]
References
- ↑ Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW et al. (September 1999). "Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage". J. Biol. Chem. 274 (34): 24176–86. doi:10.1074/jbc.274.34.24176. PMID 10446192.
- ↑ Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J et al. (September 1999). "Molecular characterization of a human DNA kinase". J. Biol. Chem. 274 (34): 24187–94. doi:10.1074/jbc.274.34.24187. PMID 10446193.
- ↑ "Entrez Gene: PNKP polynucleotide kinase 3'-phosphatase".
- ↑ 4.0 4.1 Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD et al. (January 2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell 104 (1): 107–17. doi:10.1016/S0092-8674(01)00195-7. PMID 11163244.
- ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Further reading
- Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD et al. (2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell 104 (1): 107–17. doi:10.1016/S0092-8674(01)00195-7. PMID 11163244.
- Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC (2002). "Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining". EMBO J. 21 (11): 2827–32. doi:10.1093/emboj/21.11.2827. PMC 126026. PMID 12032095.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mani RS, Karimi-Busheri F, Fanta M, Cass CE, Weinfeld M (2003). "Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex". Biochemistry 42 (41): 12077–84. doi:10.1021/bi030127b. PMID 14556639.
- Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J et al. (2004). "The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks". Cell 117 (1): 17–28. doi:10.1016/S0092-8674(04)00206-5. PMID 15066279.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M et al. (2004). "AP endonuclease-independent DNA base excision repair in human cells". Mol. Cell 15 (2): 209–20. doi:10.1016/j.molcel.2004.06.003. PMID 15260972.
- Koch CA, Agyei R, Galicia S, Metalnikov P, O'Donnell P, Starostine A et al. (2004). "Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV". EMBO J. 23 (19): 3874–85. doi:10.1038/sj.emboj.7600375. PMC 522785. PMID 15385968.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Audebert M, Salles B, Weinfeld M, Calsou P (2006). "Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway". J. Mol. Biol. 356 (2): 257–65. doi:10.1016/j.jmb.2005.11.028. PMID 16364363.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Karimi-Busheri F, Rasouli-Nia A, Allalunis-Turner J, Weinfeld M (2007). "Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination". Cancer Res. 67 (14): 6619–25. doi:10.1158/0008-5472.CAN-07-0480. PMID 17638872.
- Mani RS, Fanta M, Karimi-Busheri F, Silver E, Virgen CA, Caldecott KW et al. (2007). "XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates". J. Biol. Chem. 282 (38): 28004–13. doi:10.1074/jbc.M704867200. PMID 17650498.
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